Document Detail


Predictors of PFOA levels in a community surrounding a chemical plant.
MedLine Citation:
PMID:  19654917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Perfluorooctanoic acid (PFOA) is considered a probable human carcinogen by the U.S. Environmental Protection Agency. It does not exist in nature but has been used widely since World War II. It is present in the serum of most Americans at about 4-5 ng/mL, although the routes of exposure remain unknown.
OBJECTIVES: We examined predictors of PFOA in mid-Ohio Valley residents living near a chemical plant that until recently released large quantities of PFOA into the environment, contaminating drinking water.
METHODS: We studied 69,030 residents in six contaminated water districts who participated in a 2005-2006 survey involving a questionnaire and blood tests. Of these, 64,251 had complete data on PFOA and covariates. We also analyzed a subset (71%) for whom we had occupational history. We ran linear regression models to determine serum PFOA predictors.
RESULTS: Mean PFOA serum level was 83.0 ng/mL (median, 28.2). The most important predictors were current (median for all districts, 38.4; highest district, 224.1) and past (median, 18.6) residence in contaminated water districts, and current (median, 147.8) and past (median, 74.9) employment at the chemical plant (R(2) model = 0.55). PFOA was higher for males, those consuming local vegetables, and those using well water rather than public water, and lower for those using bottled water. PFOA was higher at younger and older ages.
CONCLUSIONS: PFOA levels in this population varied with distance of residence from the plant and employment at the plant. Effects of age and sex reflected prior findings. Effects of other demographic and lifestyle covariates were relatively weak.
Authors:
Kyle Steenland; Chuangfang Jin; Jessica MacNeil; Cathy Lally; Alan Ducatman; Veronica Vieira; Tony Fletcher
Related Documents :
20302537 - Toxicity of thiamethoxam against philippine subterranean termites.
15116847 - Bioaccumulation potential of persistent organic chemicals in humans.
10676427 - Reducing uncertainty in the derivation and application of health guidance values in pub...
20176257 - Environmental and occupational allergies.
16084977 - Soil, water, and pasture enrichment of antimony and arsenic within a coastal floodplain...
17659537 - Effectiveness of insecticide-treated and non-treated trap plants for the management of ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-23
Journal Detail:
Title:  Environmental health perspectives     Volume:  117     ISSN:  1552-9924     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-08-05     Completed Date:  2009-10-08     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1083-8     Citation Subset:  IM    
Affiliation:
Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA. nsteenl@sph.emory.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Caprylates / blood*
Chemical Industry*
Child
Child, Preschool
Female
Fluorocarbons / blood*
Humans
Infant
Infant, Newborn
Male
Middle Aged
Questionnaires
United States
Water Pollutants, Chemical / blood*
Young Adult
Chemical
Reg. No./Substance:
0/Caprylates; 0/Fluorocarbons; 0/Water Pollutants, Chemical; 335-67-1/perfluorooctanoic acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Organochlorine exposure and incidence of diabetes in a cohort of Great Lakes sport fish consumers.
Next Document:  Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healt...