Document Detail

Predictors of PFOA levels in a community surrounding a chemical plant.
MedLine Citation:
PMID:  19654917     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Perfluorooctanoic acid (PFOA) is considered a probable human carcinogen by the U.S. Environmental Protection Agency. It does not exist in nature but has been used widely since World War II. It is present in the serum of most Americans at about 4-5 ng/mL, although the routes of exposure remain unknown.
OBJECTIVES: We examined predictors of PFOA in mid-Ohio Valley residents living near a chemical plant that until recently released large quantities of PFOA into the environment, contaminating drinking water.
METHODS: We studied 69,030 residents in six contaminated water districts who participated in a 2005-2006 survey involving a questionnaire and blood tests. Of these, 64,251 had complete data on PFOA and covariates. We also analyzed a subset (71%) for whom we had occupational history. We ran linear regression models to determine serum PFOA predictors.
RESULTS: Mean PFOA serum level was 83.0 ng/mL (median, 28.2). The most important predictors were current (median for all districts, 38.4; highest district, 224.1) and past (median, 18.6) residence in contaminated water districts, and current (median, 147.8) and past (median, 74.9) employment at the chemical plant (R(2) model = 0.55). PFOA was higher for males, those consuming local vegetables, and those using well water rather than public water, and lower for those using bottled water. PFOA was higher at younger and older ages.
CONCLUSIONS: PFOA levels in this population varied with distance of residence from the plant and employment at the plant. Effects of age and sex reflected prior findings. Effects of other demographic and lifestyle covariates were relatively weak.
Kyle Steenland; Chuangfang Jin; Jessica MacNeil; Cathy Lally; Alan Ducatman; Veronica Vieira; Tony Fletcher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-23
Journal Detail:
Title:  Environmental health perspectives     Volume:  117     ISSN:  1552-9924     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-08-05     Completed Date:  2009-10-08     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1083-8     Citation Subset:  IM    
Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA.
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MeSH Terms
Caprylates / blood*
Chemical Industry*
Child, Preschool
Fluorocarbons / blood*
Infant, Newborn
Middle Aged
United States
Water Pollutants, Chemical / blood*
Young Adult
Reg. No./Substance:
0/Caprylates; 0/Fluorocarbons; 0/Water Pollutants, Chemical; 335-67-1/perfluorooctanoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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