Document Detail

Predictors of Ductus Arteriosus In-Stent Stenosis in the Hybrid Approach to Hypoplastic Left Heart Syndrome.
MedLine Citation:
PMID:  23064839     Owner:  NLM     Status:  Publisher    
The hybrid approach to palliation of hypoplastic left heart syndrome using pulmonary artery bands, a patent ductus arteriosus (PDA) stent, and atrial septostomy has been well described. One potential complication of hybrid stage 1 palliation is the development of neointimal formation and in-stent stenosis (ISS). This study aimed to identify predictors of ISS development. Patients who underwent hybrid stage 1 palliation between 2002 and 2010 were included in the study. The clinical information included oxygen saturation, weight, vital signs, and medications. Echocardiographic data included ventricular function, degree of tricuspid regurgitation, and velocity through the PDA stent and pulmonary artery bands. Hemodynamic data from interstage catheterizations were similarly noted. Patients who developed clinically significant ISS requiring either transcatheter intervention or early stage 2 repair were compared with those who did not. Of the 66 patients included in the study, 40 were boys (61 %). The median age at hybrid palliation was 7 days (range, 1-93 days), and the median initial weight was 3.2 kg (range, 1.4-5 kg). In 13 patients (20 %), ISS developed. The mean initial weight was significantly greater in the ISS group (3.5 ± 0.5 vs. 3.0 ± 0.6 kg) (p = 0.03). The mean oxygen saturations did not differ significantly between the no-ISS group (82.2 % ± 5.7 %) and the ISS group (81.4 % ± 2.0 %) (p = 0.31). The mean PDA velocities were higher in the ISS group (2.7 ± 0.4 m/s) and increased at a faster rate than in the no-ISS group at (2.4 ± 0.4 m/s) (p = 0.01). The degree of tricuspid regurgitation, ventricular function, and pulmonary artery band gradients shown by echocardiography were similar in the two groups. The development of ISS after hybrid stage 1 palliation can lead to interstage interventions or earlier comprehensive stage 2 repair. Patients with greater initial weight and a lower stent-to-weight ratio are more likely to develop ISS. The cause of ISS is complex, and additional investigation of its etiology currently is ongoing.
Holly A Nadorlik; Matthew J Egan; Sharon L Hill; John P Cheatham; Mark Galantowicz; John P Kovalchin
Related Documents :
23041689 - Management of a patient with hyperkalemic periodic paralysis requiring coronary artery ...
24581959 - Selective internal radiation therapy of hepatic tumours: is coiling of the gastroduoden...
24456739 - A novel strategy to translate the biomechanical rupture risk of abdominal aortic aneury...
24353739 - Left main coronary artery spasm in a hyperthyroid patient with suspected acute coronary...
23871199 - Two-stage hybrid repair of a complex symptomatic celiac aneurysm.
23287089 - Extradural hematoma following double valve replacement under cardiopulmonary bypass: a ...
23041689 - Management of a patient with hyperkalemic periodic paralysis requiring coronary artery ...
2949769 - Aortic valve damage caused by operative balloon dilatation of critical aortic valve ste...
25152009 - Pulmonary vein myocardium as a possible pharmacological target for the treatment of atr...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-13
Journal Detail:
Title:  Pediatric cardiology     Volume:  -     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
The Heart Center, Nationwide Children's Hospital, The Ohio State University College of Medicine, 6th Floor Education Building, 700 Children's Drive, Columbus, OH, 43205, USA,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lutembacher Syndrome With Unroofed Left Superior Vena Cava: A Diagnostic Dilemma.
Next Document:  Myocardial Perfusion Abnormalities in Patients Occurring More Than 1 Year After Successful Univentri...