Document Detail

Predictors of declining glomerular filtration rate in a population-based chronic kidney disease cohort.
MedLine Citation:
PMID:  20173349     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIM: A high percentage of patients with chronic kidney disease has nonprogressive disease. Classification with respect to rate of change in glomerular filtration rate (GFR) would permit a more targeted approach to these patients. The aim of this study was to study predictors of rate of change in GFR in a population-based cohort. METHODS: All prevalent patients with chronic kidney disease stage 3 in a well-defined population in Northern Europe between 1994 and 2003 were included. Clinical and biochemical data were collected from primary care and hospital medical records. GFR was estimated from creatinine with the recalibrated Modification of Diet in Renal Disease Study equation. Rate of change in GFR were explored in two-level multivariate linear regression models. RESULTS: A total of 1,224 patients were included. The mean age (76.5 years) was higher and mean rate of decline in GFR slower (1.5 ml/min/1.73 m(2)/year) than in studies of selected patient groups. A total of 60% of the patients suffered from comorbid conditions, 90% had hypertension. Male gender, diabetes, proteinuria and higher mean arterial pressure were independent predictors of a faster decline in GFR. CONCLUSION: The similarity of the identified predictors with those found in clinical trials of more selected patients may indicate the potential for improved treatment of older chronic kidney disease patients with multiple comorbidities by better adherence to existing guidelines.
Bjørn O Eriksen; Janne Tomtum; Ole C Ingebretsen
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Publication Detail:
Type:  Journal Article     Date:  2010-02-19
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  115     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-30     Completed Date:  2010-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c41-50     Citation Subset:  IM    
Department of Nephrology, University Hospital of North Norway, Tromsø, Norway.
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MeSH Terms
Cohort Studies
Glomerular Filtration Rate*
Kidney Failure, Chronic / diagnosis*,  epidemiology*
Norway / epidemiology
Risk Assessment / methods
Risk Factors

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