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Predictors of All-Cause 1-Year Mortality in Implantable Cardioverter Defibrillator Patients with Chronic Chagas' Cardiomyopathy.
MedLine Citation:
PMID:  21535031     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Implantable cardioverter defibrillators (ICDs) have been used in the treatment of either sustained ventricular tachycardia or ventricular fibrillation in patients with Chagas' cardiomyopathy. This study aimed at determining mortality rate and risk factors of all-cause 1-year mortality in primary and secondary ICD patients with Chagas' cardiomyopathy. Methods: One hundred and forty-eight Chagas' patients with ICDs were included from the Medtronic ICD Registry Latin America. All patients were followed for 1 year. Results: At implant, mean age was 60.1 ± 9.4 years and 72.9% were male. Mean left ventricular ejection fraction (LVEF) was 40.1 ± 11%. Mean follow-up was 12 ± 7 months. During the follow-up, 15 patients died (10.2%). Patients who died were older (64 ±10.8 years vs 59 ± 9.1; P = 0.04), had more atrial fibrillation (13.3% vs 3.8%; P = 0.02), had lower LVEF (33.4%± 9.8 vs 40.9%± 11.3; P = 0.01), and worse functional class (III/IV 40% vs 21.8%; P = 0.03). The multivariate analysis showed that two independent predictors of all-cause 1-year mortality remained statistically significant: age more than 65 (hazard ratio [HR] = 2.85, 95% confidence interval [CI] 1.77-3.92; P = 0.03) and LVEF less than 30% (HR = 2.68, 95% CI 1.57-3.79; P = 0.04). Conclusion: This analysis showed that patients older than 65 years of age and with LVEF less than 30% were independent predictors of all-cause 1-year mortality in patients with chronic Chagas' cardiomyopathy.(PACE 2011; 1-7).
Authors:
Darío DI Toro; Claudio Muratore; Luis Aguinaga; Luiz Batista; Antonio Malan; Oswaldo Greco; Chamia Benchetrit; Mauricio Duque; Adrian Baranchuk; Jennifer Maloney
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-28
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  -     ISSN:  1540-8159     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©2011, The Authors. Journal compilation ©2011 Wiley Periodicals, Inc.
Affiliation:
Hospital Argerich, Buenos Aires, Argentina Hospital Fernández, Buenos Aires, Argentina Centro Privado de Cardiología, Tucumán, Argentina Centro Medico Medvitta Ltda., Goiana, Brazil Ritmovida, Goiana, Brazil I de Molestias Cardiovasculares, Sao José do Río Preto, Brazil Hospital Universitario de Caracas, Caracas, Venezuela Clínica Medellín, Medellín, Colombia Kignston General Hospital, Queen's University, Kingston, Ontario, Canada Medtronic Inc., Minneapolis, Minnesota.
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