Document Detail


Predictors of active injection drug use in a cohort of patients infected with hepatitis C virus.
MedLine Citation:
PMID:  23153145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We investigated potential risk factors for active injection drug use (IDU) in an inner-city cohort of patients infected with hepatitis C virus (HCV).
METHODS: We used log-binomial regression to identify factors independently associated with active IDU during the first 3 years of follow-up for the 289 participants who reported ever having injected drugs at baseline.
RESULTS: Overall, 142 (49.1%) of the 289 participants reported active IDU at some point during the follow-up period. In a multivariate model, being unemployed (prevalence ratio [PR] = 1.93; 95% confidence interval [CI] = 1.24, 3.03) and hazardous alcohol drinking (PR = 1.67; 95% CI = 1.34, 2.08) were associated with active IDU. Smoking was associated with IDU but this association was not statistically significant. Patients with all 3 of those factors were 3 times as likely to report IDU during follow-up as those with 0 or 1 factor (PR = 3.3; 95% CI = 2.2, 4.9). Neither HIV coinfection nor history of psychiatric disease was independently associated with active IDU.
CONCLUSIONS: Optimal treatment of persons with HCV infection will require attention to unemployment, alcohol use, and smoking in conjunction with IDU treatment and prevention.
Authors:
Carrie Reed; Caleb Bliss; Sherri O Stuver; Timothy Heeren; Sheila Tumilty; C Robert Horsburgh; Jeffrey H Samet; Deborah J Cotton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-15
Journal Detail:
Title:  American journal of public health     Volume:  103     ISSN:  1541-0048     ISO Abbreviation:  Am J Public Health     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-02-21     Revised Date:  2014-04-07    
Medline Journal Info:
Nlm Unique ID:  1254074     Medline TA:  Am J Public Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-11     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcoholism / complications
Cohort Studies
Female
Follow-Up Studies
Hepacivirus
Hepatitis C / complications*
Humans
Male
Middle Aged
Prevalence
Regression Analysis
Risk Factors
Smoking / adverse effects
Substance Abuse, Intravenous / diagnosis*,  etiology*
Unemployment
Young Adult
Grant Support
ID/Acronym/Agency:
DA19841/DA/NIDA NIH HHS; R01 DA019841/DA/NIDA NIH HHS; T32 GM074905/GM/NIGMS NIH HHS
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