Document Detail

Predictive value of synovial fluid analysis in rheumatoid arthritis. A 7.5-year follow-up study.
MedLine Citation:
PMID:  8252159     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the prognostic value of some synovial fluid variables in patients with rheumatoid arthritis. METHODS: Twenty-nine patients with erosive rheumatoid arthritis and hydropsy in a knee joint were followed for 7.5 years in a prospective study. At the start of the study the knee joints were aspirated and 15 synovial fluid variables were analyzed. The patients were divided into two groups according to whether or not there had been progress of radiologically detected destruction in the knee joints during the follow-up. RESULTS: Of the synovial fluid variables at the start, only C3 (p = 0.030) and acid phosphatase (p = 0.047) differed significantly between the groups, the former being lower and the latter higher in patients with deterioration of knee joints. CONCLUSIONS: These preliminary results may indicate that low synovial fluid C3 and high acid phosphatase predict poor prognosis in a joint affected by rheumatoid arthritis.
R Luukkainen; A Alanaatu; K Kaarela; H Huhtala
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European journal of medicine     Volume:  2     ISSN:  1165-0478     ISO Abbreviation:  Eur J Med     Publication Date:  1993 May 
Date Detail:
Created Date:  1994-01-11     Completed Date:  1994-01-11     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9209793     Medline TA:  Eur J Med     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  284-6     Citation Subset:  IM    
Satalinna Hospital, Harjavalta, Finland.
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MeSH Terms
Acid Phosphatase / analysis
Arthritis, Rheumatoid / diagnosis*
Complement C3 / analysis
Follow-Up Studies
Knee Joint
Middle Aged
Predictive Value of Tests
Prospective Studies
Synovial Fluid / chemistry*,  cytology*
Reg. No./Substance:
0/Complement C3; EC Phosphatase

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