Document Detail


Predictive value of serum-soluble CD154 in fulminant hepatic failure.
MedLine Citation:
PMID:  18652769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interaction of CD40 with CD154 is a pivotal trigger of immune cascade-inducing acute liver failure, however its clinical significance has not been well studied. The present study aimed to investigate the clinical implications of serum-soluble CD154 (sCD154) levels and the expression of CD40 on monocytes in patients with fulminant hepatic failure (FHF). The results showed that serum sCD154 levels and CD40 expression on monocytes were significantly higher in FHF patients than in acute hepatitis (AH) patients and healthy controls, and were also significantly higher in FHF patients who died, compared with those who survived. We conclude that high serum levels of sCD154 may be linked to fatal outcome in patients with severe liver injury and may be a valuable prognostic marker for survival in patients with FHF.
Authors:
Y B Zheng; Z L Gao; F Zhong; Y S Huang; L Peng; B L Lin; Y T Chong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of international medical research     Volume:  36     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2008-07-25     Completed Date:  2008-09-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  728-33     Citation Subset:  IM    
Affiliation:
Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
CD40 Ligand / blood*,  immunology
Female
Humans
Liver Failure, Acute / blood*,  diagnosis,  immunology*
Male
Monocytes / cytology,  metabolism
Predictive Value of Tests
Prognosis
Chemical
Reg. No./Substance:
147205-72-9/CD40 Ligand

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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