Document Detail


Predictive value of preintervention C-reactive protein on clinical outcome after directional coronary atherectomy followed by stent implantation.
MedLine Citation:
PMID:  17765643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Preprocedural C-reactive protein (CRP) serum levels have been shown to predict the recurrence of angina or major adverse cardiac events after percutaneous coronary intervention. Directional coronary atherectomy (DCA), by reducing residual plaque burden and restenosis, has been shown to improve clinical outcome after coronary stenting. Thus, we assessed the influence of preprocedural CRP serum levels on the recurrence of cardiac events after DCA followed by bare metal stent implantation. METHODS: We enrolled 40 consecutive patients (34 males; 61+/-10 years old) with single-vessel disease who were undergoing DCA. In all patients, preprocedural CRP serum levels were measured by an ultrasensitive nephelometric method. The endpoint of the study was defined as the composite incidence of death, myocardial infarction, and recurrence of angina requiring repeat revascularization at 6-month follow-up. RESULTS: CRP serum levels were a significant independent predictor of the composite endpoint at multiple regression analysis [odds ratio=1.69; 95% confidence interval (95% CI)=1.04-2.75; P=.033]. Patients with recurrence of cardiac events had CRP serum levels higher than those of patients not having events on follow-up [3.95 (2.2-5.7) vs. 2 (1.3-3.3); P=.05]. CONCLUSION: In conclusion, our study shows that baseline CRP serum levels predict cardiac events after coronary bare metal stenting despite plaque debulking with directional atherectomy.
Authors:
Giampaolo Niccoli; Giuseppe Ferrante; Rocco Mongiardo; Matteo Perfetti; Flavia Belloni; Francesco Burzotta; Italo Porto; Antonio Maria Leone; Antonio G Rebuzzi; Filippo Crea
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Cardiovascular revascularization medicine : including molecular interventions     Volume:  8     ISSN:  1553-8389     ISO Abbreviation:  -     Publication Date:    2007 Jul-Sep
Date Detail:
Created Date:  2007-09-03     Completed Date:  2007-11-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101238551     Medline TA:  Cardiovasc Revasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  156-60     Citation Subset:  IM    
Affiliation:
Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy. gniccoli73@hotmail.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Angina Pectoris / blood,  etiology*,  therapy
Angioplasty, Transluminal, Percutaneous Coronary / adverse effects,  instrumentation*
Atherectomy, Coronary*
C-Reactive Protein / metabolism*
Coronary Artery Disease / blood,  complications,  mortality,  therapy*
Coronary Restenosis / blood,  etiology
Female
Follow-Up Studies
Humans
Logistic Models
Male
Metals
Middle Aged
Myocardial Infarction / blood,  etiology
Nephelometry and Turbidimetry / methods
Odds Ratio
Predictive Value of Tests
Prosthesis Design
Risk Assessment
Risk Factors
Stents*
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Metals; 9007-41-4/C-Reactive Protein

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