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Predictive value of neonatal brain MRI on the neurodevelopmental outcome of preterm infants by 5 years of age.
MedLine Citation:
PMID:  23398524     Owner:  NLM     Status:  Publisher    
AIM: To study the prognostic value of MRI in preterm infants at term equivalent age for cognitive development at 5 years of age. METHODS: A total of 217 very low birth weight/very low gestational age infants who all received brain MRI at term equivalent age were categorized into 4 groups based on the brain MRI findings. Cognitive development was assessed at 5 years of chronological age by using a short form of Wechsler Preschool and Primary Scale of Intelligence - Revised. This information was combined with neurosensory diagnoses by 2 years of corrected age. RESULTS: Of all infants 31 (17.0%) had Full Scale Intelligence Quotient (FSIQ) <85, 14 (6.5%) had cerebral palsy and 4 (1.8%) had severe hearing impairment. A total of 41 (22.0%) infants had some neurodevelopmental impairment at 5 years of age. Considering cognitive outcome (FSIQ <85), the positive predictive value of several major MRI pathologies was 43.8%, and the negative predictive value of normal finding or minor pathologies was 92.0% and 85.7%, respectively. CONCLUSION: The MRI of the brain at term equivalent age may be valuable in predicting neurodevelopmental outcome in preterm infants by 5 years of age. The findings should always be interpreted alongside the clinical information of the infant. Furthermore, MRI should not replace a long-term clinical follow-up for very preterm infants. ©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.
Sirkku Setänen; Leena Haataja; Riitta Parkkola; Annika Lind; Liisa Lehtonen;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-7
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.
Department of Pediatric Neurology, Turku University Hospital, Finland; Department of Medicine, University of Turku, Finland.
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