| Predictive value of heart-type fatty acid-binding protein for left ventricular remodelling and clinical outcome of hypertensive patients with mild-to-moderate aortic valve diseases. | |
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MedLine Citation:
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PMID: 17392813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heart-type fatty acid-binding protein (H-FABP), a marker of acute myocardial infarction and a soluble cytosolic protein, may be released following left ventricular remodelling in cardiac overloaded hearts caused by hypertension, aortic regurgitation (AR) or aortic stenosis (AS). Our aim was to investigate if H-FABP levels are associated with left ventricular remodelling and clinical outcome in hypertensive patients with AR or AS. H-FABP and brain natriuretic peptide (BNP) were measured, glomerular filtration rate (GFR) was estimated using the modification of diet in renal disease (MDRD) equation, and left ventricular dimension at systole corrected for body surface area (LVDs/BSA) and relative wall thickness (RWT) were determined by echocardiography in hypertensive patients with mild-to-moderate AR (n=78), those with mild-to-moderate AS (n=73) and those without valvular heart diseases (HT) (n=50). H-FABP levels were significantly higher in AR (4.9+/-3 ng/ml) and in AS (4.5+/-3) than in HT (3.4+/-1) and BNP (65+/-73 pg/ml, 76+/-75, 35+/-22). H-FABP correlated with LVDs/BSA in AR (beta=0.23, P<0.05), and RWT in AS (beta=0.18, P<0.05) after adjustment for age, gender and all the other variables. AS and AR patients were prospectively followed up for cardiac events during 34+/-19 months. A multivariate Cox hazard analysis indicated H-FABP was an independent predictor of outcome both in AR (relative risk (RR)=7.61, 95% CI=2.39-25.3) and AS (RR=13.6, 95% CI=3.27-66.9). H-FABP, associated with left ventricular remodelling, is useful in predicting clinical outcome in hypertensive patients with mild-to-moderate aortic valve diseases. |
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Authors:
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M Iida; M Yamazaki; H Honjo; I Kodama; K Kamiya |
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Publication Detail:
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Type: Journal Article Date: 2007-03-29 |
Journal Detail:
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Title: Journal of human hypertension Volume: 21 ISSN: 0950-9240 ISO Abbreviation: J Hum Hypertens Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-21 Completed Date: 2007-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 551-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Mitsubishi Nagoya Hospital, 7-8 Sotodoi-cho, Atsuta-ku, Nagoya 456-0013, Japan. masato2_iida@mhi.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aortic Valve Insufficiency / blood*, complications, mortality Aortic Valve Stenosis / blood*, complications, mortality Biological Markers / blood Echocardiography Fatty Acid-Binding Proteins / blood* Female Humans Hypertension / blood*, complications, mortality Male Middle Aged Natriuretic Peptides / blood Predictive Value of Tests Prospective Studies Survival Analysis Ventricular Remodeling / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fatty Acid-Binding Proteins; 0/Natriuretic Peptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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