| Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. | |
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MedLine Citation:
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PMID: 18498767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: An association between white blood cell count (WBC), severity of coronary artery disease (CAD) and survival has been described in patients with acute coronary syndrome. Our aim was to analyze the predictive ability for cardiac events of differential WBC, which is still not well characterized, against established risk factors in angiographically proven CAD patients. METHODS: We prospectively evaluated complete blood count, biomarkers of inflammation [(C-reactive protein (CRP) and serum iron (SI)], glucose/lipid metabolism [(fasting glucose (FG), total, high-density lipoprotein (HDL) and low-density lipoprotein cholesterol] and established risk factors in 422 consecutive ischemic patients with angiographically documented stable CAD. On a 3-year follow-up, cardiac death and non-fatal myocardial infarction (MI) were considered as end-points. RESULTS: At multivariate analysis neutrophil to lymphocyte ratio (N/L) emerged as independent predictor of cardiac death (HR 8.13; p=0.02) together with CRP, left ventricular ejection fraction (LVEF), FG, HDL and SI. CRP, LVEF, and HDL showed an independent prognostic value for cardiac death and non-fatal MI. Event-free survival according to N/L tertiles was 99% for the first tertile (1.23+/-0.26), 96.5% for the second (2.05+/-0.29), and 88.8% for the third one (5.19+/-3.81). CONCLUSIONS: N/L is an independent predictor of cardiac mortality in stable CAD patients. |
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Authors:
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Angela Papa; Michele Emdin; Claudio Passino; Claudio Michelassi; Debora Battaglia; Franca Cocci |
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Publication Detail:
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Type: Journal Article Date: 2008-05-01 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 395 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-07-28 Completed Date: 2008-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 27-31 Citation Subset: IM |
Affiliation:
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Institute of Clinical Physiology, National Research Council, Pisa, Italy. angela@ifc.cnr.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged C-Reactive Protein / analysis Cholesterol, HDL / metabolism Cholesterol, LDL / metabolism Coronary Artery Disease / diagnosis* Disease-Free Survival Female Follow-Up Studies Glucose / metabolism Humans Iron / blood Lymphocyte Count Lymphocytes / pathology* Male Middle Aged Multivariate Analysis Neutrophils / pathology* Predictive Value of Tests Prognosis Prospective Studies Risk Assessment Risk Factors Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 50-99-7/Glucose; 7439-89-6/Iron; 9007-41-4/C-Reactive Protein |
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