Document Detail

Predictive value of electromyography in diagnosis and prognosis of the hypotonic infant.
MedLine Citation:
PMID:  1469246     Owner:  NLM     Status:  MEDLINE    
To investigate the diagnostic validity of electromyography in the hypotonic infant, 79 children aged 0 to 12 months, seen over a 20-year period, were studied retrospectively. The diagnoses using clinical, muscle biopsy, and laboratory characteristics were: 25 central hypotonia, 20 spinal muscular atrophy, 20 myopathy, four myotonic dystrophy, four benign congenital hypotonia, two congenital muscular dystrophy, two myasthenia gravis, one infantile inflammatory myopathy, and one arthrogryposis multiplex congenita. Using strict criteria, electromyography accurately predicted the final diagnosis in 65% of infants with spinal muscular atrophy and was consistent with the diagnosis in another 25%. In contrast, electromyography accurately predicted the final diagnosis in only 10% of infants with myopathy and was normal in 88% of infants with central hypotonia. In infants with spinal muscular atrophy, there was no difference in the predictive value of electromyography when performed in the newborn compared to older infants. Normal distal nerve conduction velocities in infants with spinal muscular atrophy may predict prognosis, since these infants had a longer survival. Electromyography thus has a high predictive value for infantile spinal muscular atrophy but not for myopathy.
J W Russell; A K Afifi; M A Ross
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of child neurology     Volume:  7     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1993-01-26     Completed Date:  1993-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  387-91     Citation Subset:  IM    
Department of Neurology, Faculty of Medicine, University of Iowa, Iowa City.
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MeSH Terms
Hospital Records
Infant, Newborn
Infant, Newborn, Diseases
Microscopy, Electron
Muscle Hypotonia / complications,  diagnosis*,  physiopathology
Muscles / physiopathology*
Neural Conduction
Neurologic Examination
Spinal Muscular Atrophies of Childhood / etiology,  physiopathology*
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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