Document Detail

Predictive value of early serum beta-hCG levels after single blastocyst transfer.
MedLine Citation:
PMID:  19878087     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Analysis of serum beta-human chorionic gonadotropin (beta-hCG) levels on standardized days after oocyte retrieval (OR) following single blastocyst transfer to predict pregnancy outcome after assisted reproductive technology. DESIGN: Retrospective study. SETTING: Private fertility center. POPULATION: A total of 230 women with an intact intrauterine pregnancy 21 days after OR and a vital term delivery (n = 191) or a miscarriage (< 10+0 gestational weeks) (n = 39) in the course of the pregnancy following single blastocyst transfer between 1999 and 2008. METHODS: Blood was sampled 11, 14 and partly 21 days after OR. The serum concentration of total beta-hCG was measured by an automated quantitative immunoassay. Receiver operating characteristic curves were generated to calculate sensitivity and specificity. MAIN OUTCOME MEASURES: A total of 509 beta-hCG measurements. RESULTS: The mean beta-hCG concentrations on days 11, 14 and 21 after OR were significantly lower in the group of patients with a miscarriage compared to the group with a term delivery (p = 0.02, < 0.001 and < 0.001 respectively). With the cut-off values of 15 mIU/mL, 80 mIU/mL and 1500 mIU/mL on days 11, 14 and 21, the positive predictive value was 89%, 93% and 92%. The negative predictive value was 28%, 40% and 54%. CONCLUSIONS: The predictive value of a single beta-hCG measurement for pregnancy outcome after single blastocyst transfer increases between days 11 and 21 after OR. A single beta-hCG measurement on day 14 may balance the accuracy of prediction and the necessity of an early reassuring test.
Robert Ochsenk??hn; Andrea Arzberger; Viktoria von Sch??nfeldt; Jutta Engel; Christian J Thaler; Ulrich Noss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  88     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  1382-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology - Grosshadern University Hospital, Ludwig-Maximilians-University, Marchioninistrasse 15, 81377 Munich, Germany.
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MeSH Terms
Chorionic Gonadotropin, beta Subunit, Human / blood*
Embryo Transfer*
Oocyte Retrieval*
Predictive Value of Tests
ROC Curve
Retrospective Studies
Sensitivity and Specificity
Time Factors
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human

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