| Predictive value of early serum beta-hCG levels after single blastocyst transfer. | |
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MedLine Citation:
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PMID: 19878087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Analysis of serum beta-human chorionic gonadotropin (beta-hCG) levels on standardized days after oocyte retrieval (OR) following single blastocyst transfer to predict pregnancy outcome after assisted reproductive technology. DESIGN: Retrospective study. SETTING: Private fertility center. POPULATION: A total of 230 women with an intact intrauterine pregnancy 21 days after OR and a vital term delivery (n = 191) or a miscarriage (< 10+0 gestational weeks) (n = 39) in the course of the pregnancy following single blastocyst transfer between 1999 and 2008. METHODS: Blood was sampled 11, 14 and partly 21 days after OR. The serum concentration of total beta-hCG was measured by an automated quantitative immunoassay. Receiver operating characteristic curves were generated to calculate sensitivity and specificity. MAIN OUTCOME MEASURES: A total of 509 beta-hCG measurements. RESULTS: The mean beta-hCG concentrations on days 11, 14 and 21 after OR were significantly lower in the group of patients with a miscarriage compared to the group with a term delivery (p = 0.02, < 0.001 and < 0.001 respectively). With the cut-off values of 15 mIU/mL, 80 mIU/mL and 1500 mIU/mL on days 11, 14 and 21, the positive predictive value was 89%, 93% and 92%. The negative predictive value was 28%, 40% and 54%. CONCLUSIONS: The predictive value of a single beta-hCG measurement for pregnancy outcome after single blastocyst transfer increases between days 11 and 21 after OR. A single beta-hCG measurement on day 14 may balance the accuracy of prediction and the necessity of an early reassuring test. |
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Authors:
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Robert Ochsenk??hn; Andrea Arzberger; Viktoria von Sch??nfeldt; Jutta Engel; Christian J Thaler; Ulrich Noss |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 88 ISSN: 1600-0412 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2009 |
Date Detail:
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Created Date: 2009-12-07 Completed Date: 2010-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: England |
Other Details:
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Languages: eng Pagination: 1382-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology - Grosshadern University Hospital, Ludwig-Maximilians-University, Marchioninistrasse 15, 81377 Munich, Germany. Robert.Ochsenkuehn@med.uni-muenchen.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Gonadotropin, beta Subunit, Human / blood* Embryo Transfer* Female Humans Oocyte Retrieval* Predictive Value of Tests Pregnancy ROC Curve Retrospective Studies Sensitivity and Specificity Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin, beta Subunit, Human |
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