Document Detail

Predictive value of coronary calcifications for future cardiac events in asymptomatic individuals.
MedLine Citation:
PMID:  18082507     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Reliable risk stratification is crucial for efficient prevention of coronary artery disease. The following prospective study determined the predictive value of coronary calcifications for future cardiovascular events. METHODS: We included 1726 asymptomatic individuals (1018 men, 708 women, age 57.7 +/- 13.3 years) referred for a cardiological examination. Coronary calcifications were determined with the Imatron C 150 XP electron beam computed tomography scanner. For quantification of coronary calcifications, we calculated the Agatston score. Over a mean observation period of 40.3 +/- 7.3 months we registered the event rate for cardiac death (CD) and myocardial infarction (MI). RESULTS: The Agatston score in patients who died of CD (n = 65) or had an MI (n = 114) was significantly higher compared with those without cardiac events (458 +/- 228 vs 206 +/- 201, P < .01). An Agatston score above the 75th percentile was associated with a significantly higher annualized event rate for MI (3.6% vs 1.6%, P < .05) and for CD (2.2% vs 0.9%) compared with patients with scores below the 75th percentile. No cardiac events were observed in patients where coronary calcifications could be excluded. CONCLUSIONS: By determination of coronary calcifications, patients at risk for future MI and CD could be identified within an asymptomatic population independent of concomitant risk factors. At the same time, future cardiovascular events could be excluded in patients without coronary calcifications.
Alexander Becker; Alexander Leber; Christoph Becker; Andreas Knez
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Publication Detail:
Type:  Journal Article     Date:  2007-10-17
Journal Detail:
Title:  American heart journal     Volume:  155     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-17     Completed Date:  2008-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  154-60     Citation Subset:  AIM; IM    
Department of Cardiology, Ludwig-Maximilians-University, Munich, Germany.
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MeSH Terms
Age Distribution
Analysis of Variance
Calcinosis / diagnosis*,  epidemiology*
Cohort Studies
Confidence Intervals
Coronary Angiography
Coronary Artery Disease / diagnosis*,  epidemiology*
Echocardiography, Doppler
Exercise Test
Mass Screening
Middle Aged
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
Reference Values
Risk Assessment
Sex Distribution
Tomography, Emission-Computed, Single-Photon

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