| Predictive value of clinical, laboratory, pathologic, and treatment variables in steroid/immunosuppressive resistant lupus nephritis. | |
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MedLine Citation:
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PMID: 3391988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-seven patients with lupus nephritis and nephrotic syndrome had persistent disease activity despite an adequate trial of corticosteroids and immunosuppressive drugs; 30% were Asians, compared with 7% of our overall SLE population. Two years later, seven had a very good outcome and seven a poor outcome. Thirty clinical, pathological, laboratory, and treatment variables were analyzed in a good versus poor responder subset comparison in an effort to determine which factors were associated with favorable outcome. Administration of pulse steroids (P = .069) and a low biopsy chronicity index (P = .048) were associated with the good responder subset. Serum creatinine, biopsy class, blood pressure, complement, and anti-DNA values at entry as well as the choice of immunosuppressive drug were not helpful in predicting outcome. All seven good responders were plasmapheresed (P = .026). Patients with refractory lupus nephritis who have a low biopsy chronicity index may benefit from the use of pulse steroids or plasmapheresis, and controlled studies are suggested. |
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Authors:
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D J Wallace; D Goldfinger; G Savage; S Nichols; D Goodman; M Fichman; M Stewart; J R Klinenberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical apheresis Volume: 4 ISSN: 0733-2459 ISO Abbreviation: J Clin Apher Publication Date: 1988 |
Date Detail:
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Created Date: 1988-08-19 Completed Date: 1988-08-19 Revised Date: 2005-07-26 |
Medline Journal Info:
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Nlm Unique ID: 8216305 Medline TA: J Clin Apher Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 30-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, UCLA School of Medicine. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dose-Response Relationship, Drug Female Follow-Up Studies Glucocorticoids / administration & dosage* Humans Immunosuppressive Agents / administration & dosage* Lupus Nephritis / metabolism, pathology, therapy* Male Nephrotic Syndrome / metabolism, pathology, therapy* Plasmapheresis / methods* Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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