Document Detail


Predictive value of T-wave alternans for arrhythmic events in patients with congestive heart failure.
MedLine Citation:
PMID:  10968440     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Measurement of microvolt level T-wave alternans in the surface electrocardiogram is a novel way to assess the risk of ventricular arrhythmias. Seven tests of arrhythmic risk, including T-wave alternans, were undertaken in 107 consecutive patients with congestive heart failure and no history of sustained ventricular arrhythmias; the patients were followed up for arrhythmic events during the next 18 months. Of the patients with events, 11 had positive and two indeterminate T-wave alternans results; there were no arrhythmic events among patients with negative T-wave alternans results. Of the seven tests, only T-wave alternans was a significant (p=0.0036) and independent predictor of arrhythmic events.
Authors:
T Klingenheben; M Zabel; R B D'Agostino; R J Cohen; S H Hohnloser
Publication Detail:
Type:  Clinical Trial; Letter    
Journal Detail:
Title:  Lancet     Volume:  356     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-20     Completed Date:  2000-09-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  651-2     Citation Subset:  AIM; IM; S    
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MeSH Terms
Descriptor/Qualifier:
Arrhythmias, Cardiac / diagnosis*,  etiology*,  physiopathology
Electrocardiography*
Female
Follow-Up Studies
Heart Failure / complications*,  physiopathology
Humans
Male
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Proportional Hazards Models
Risk Assessment
Survival Rate
Investigator
Investigator/Affiliation:
R J Cohen / MA Inst Tech, Cambridge

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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