| Predictive value of FDG PET/CT for pathologic axillary node involvement after neoadjuvant chemotherapy. | |
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MedLine Citation:
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PMID: 22311581 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The purpose of this study was to determine the usefulness of sequential FDG PET/CTs for prediction of axillary lymph node (ALN) status after neoadjuvant chemotherapy (NAC). METHODS: Seventy-seven stage II or III breast cancer patients who received 3 cycles of neoadjuvant docetaxel/doxorubicin chemotherapy were enrolled in this prospective study. FDG PET/CTs were acquired before chemotherapy and after the first cycle of chemotherapy for early metabolic response prediction. RESULTS: Patients with pN0 had significantly lower post-NAC ALN standard uptake value (SUV) than those who were pN+ (1.22 ± 1.46 in pN0 vs. 2.13 ± 1.99 in pN+, P = 0.017). Post-NAC ALN size on CT also differed according to pathologic ALN status (6.3 mm in pN0 vs. 11.1 mm in pN+, P = 0.014). When serial FDG PET/CT and chest CT were used, patients with an SUV > 1.5 and post-NAC ALN size ≥10 mm on CT did not achieve pN0 (specificity 100% and positive predictive value 100%). CONCLUSIONS: The serial FDG PET/CT after NAC could predict the pathologic status of ALN before surgery in stage II/III breast cancer. Our findings suggest that the combined use of serial FDG PET/CTs and chest CT might provide better information regarding ALN before surgery. |
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Authors:
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Bhumsuk Keam; Seock-Ah Im; Youngil Koh; Sae-Won Han; Do-Youn Oh; Nariya Cho; Jee Hyun Kim; Wonshik Han; Keon Wook Kang; Woo Kyung Moon; Tae-You Kim; In Ae Park; Dong-Young Noh; June-Key Chung; Yung-Jue Bang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-7 |
Journal Detail:
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Title: Breast cancer (Tokyo, Japan) Volume: - ISSN: 1880-4233 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888201 Medline TA: Breast Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul, 110-744, Korea, bhumsuk@snu.ac.kr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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