Document Detail

Predictive significance of bone sialoprotein and osteopontin for bone metastases in resected Chinese non-small-cell lung cancer patients: a large cohort retrospective study.
MedLine Citation:
PMID:  19376608     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Bone is one of the most common sites of metastasis in patients with non-small-cell lung cancer (NSCLC). Over-expression of bone sialoprotein (BSP) and osteopontin (OPN) in tumour samples has shown prognostic significance in bone metastasis (BM) of breast and prostate cancer, respectively. However, their importance in BM of NSCLC has not been verified. Therefore, we planned a large cohort retrospective study to investigate the relationship between the expression of these two biomarkers (BSP and OPN) and BM in surgically resected NSCLC patients. METHODS: 180 completely resected NSCLC patients were included in this study. 40 patients subsequently developed BM. Paraffin-embedded primary tumour tissues of patients were supplied to produce a tissue microarray, and immunohistochemistry method was used for evaluation of the expression of BSP and OPN. Different expressions of these two biomarkers among BM group and non-BM group were estimated by chi(2) test. BM-free survival was analyzed by Kaplan-Meier method. The prognostic impact of clinicopathologic variables and biomarker expression was evaluated by Cox proportional hazards model. RESULTS: BSP expression was associated with BM (p=0.007), whereas OPN expression did not reach statistical significance (p=0.245). Univariate analysis showed that expression of BSP (p=0.010) and N staging (p<0.005) was associated with BM-free survival. Multivariate analyses showed BSP expression (HR=3.322, p=0.003), N staging (HR=1.879, p=0.001), and T staging (HR=1.618, p=0.024) were independent prognostic factors for BM. CONCLUSIONS: BSP protein expression in the primary resected NSCLC is strongly associated with BM and could be used to identify high-risk patients. Correlation of OPN protein expression and BM needs further investigation.
Li Zhang; Xue Hou; Shun Lu; Huilan Rao; Jinghui Hou; Rongzhen Luo; He Huang; Hongyun Zhao; Hong Jian; Zhiwei Chen; Meilin Liao; Xin Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lung cancer (Amsterdam, Netherlands)     Volume:  67     ISSN:  1872-8332     ISO Abbreviation:  Lung Cancer     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800805     Medline TA:  Lung Cancer     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  114-9     Citation Subset:  IM    
Department of Medical Oncology, Cancer Center of Sun Yat-Sen University, Guangzhou, China.
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MeSH Terms
Aged, 80 and over
Asian Continental Ancestry Group
Bone Neoplasms / diagnosis*,  secondary
Carcinoma, Non-Small-Cell Lung / pathology,  surgery*
Cohort Studies
Lung Neoplasms / pathology,  surgery*
Middle Aged
Osteopontin / biosynthesis*
Retrospective Studies
Sialoglycoproteins / biosynthesis*
Tumor Markers, Biological / biosynthesis*
Reg. No./Substance:
0/Sialoglycoproteins; 0/Tumor Markers, Biological; 0/integrin-binding sialoprotein; 106441-73-0/Osteopontin

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