| Predictive significance of TCI-R for antidepressant treatment. | |
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MedLine Citation:
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PMID: 20671615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to investigate the significance of the Temperament and Character Inventory-Revised (TCI-R) dimensions of personality for prediction of treatment outcome in depressed outpatients during 6 months of antidepressant treatment. MATERIAL/METHODS: Thirty outpatients were treated for mild or moderate depressive episode, current mild or moderate episode of recurrent depressive disorder or mixed anxiety and depressive disorder (ICD-10). The intensity of depression was assessed by the Montgomery-Asberg Depression Rating Scale (MADRS) at the beginning of treatment and then after the 1st, 3rd and 6th months of treatment. The personality dimensions were assessed by the TCI-R at the same time points as the MADRS. Differences in TCI-R dimensions between treatment responders (> or =50% decrease in MADRS score after 6 months of treatment) and nonresponders (<50% decrease in MADRS score) were compared by repeated measures analysis of variance (ANOVA). Predictive value for the treatment outcome was assessed by Spearman's correlation coefficient. RESULTS: The predictive significance for treatment outcome (Spearman's correlation coefficient) was identified for reward dependence (RD) (R=-0.44) and harm avoidance (HA) (R=0.46) dimensions. Treatment responders and nonresponders significantly differed (ANOVA) in HA (p<0.05), showing a decrease in total mean HA score only in responders during treatment. CONCLUSIONS: Our findings showed predictive significance of the TCI-R dimensions HA and RD for long-term antidepressant treatment outcome. |
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Authors:
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Radovan Hruby; Gabriela Nosalova; Sabina Hruba |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 16 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-30 Completed Date: 2010-11-03 Revised Date: 2011-06-14 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: CR383-8 Citation Subset: IM |
Affiliation:
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Institute of Pharmacology, Jessenius Faculty of Medicine, Martin, Slovak Republic. radhru@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Antidepressive Agents / therapeutic use* Avoidance Learning / drug effects Character* Depressive Disorder / drug therapy* Humans Personality Inventory* Predictive Value of Tests Psychiatric Status Rating Scales Temperament* / drug effects Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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