Document Detail

Predictive power of maternal serum and amniotic fluid CRP and PAPP-A concentrations at the time of genetic amniocentesis for the preterm delivery.
MedLine Citation:
PMID:  16219520     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate whether maternal serum and amniotic fluid CRP and PAPP-A concentrations at the time of genetic amniocentesis are markers of preterm delivery. STUDY DESIGN: One hundred and forty-one pregnant women were included in this prospective study. Amniotic fluid and maternal serum CRP and PAPP-A concentrations were determined by using commercially available kits. Receiver-operating characteristic (ROC) analysis was performed to determine the efficacy of maternal serum and amniotic fluid CRP and PAPP-A levels in predicting women with preterm delivery. RESULTS: The prevalence of spontaneous preterm delivery before 37 weeks of gestation was 9.9%. ROC analysis revealed that amniotic fluid CRP level was the only parameter, which had a significant power in the prediction of preterm delivery. The optimum cut-off level was 0.65 mg/L. The sensitivity and specificity were 92.9% and 78.7%, respectively. CONCLUSION: The amniotic fluid CRP level has a high sensitivity and specificity in the prediction of preterm delivery and this may be helpful in predicting preterm delivery during genetic amniocentesis.
Kamer T Ozer; Zehra N Kavak; Hüsnü Gökaslan; Koray Elter; Tanju Pekin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  122     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-12     Completed Date:  2006-01-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  187-90     Citation Subset:  IM    
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Marmara University School of Medicine, Istanbul, Turkey.
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MeSH Terms
Amniotic Fluid / metabolism*
Biological Markers
C-Reactive Protein / metabolism*
Genetic Testing
Predictive Value of Tests
Pregnancy-Associated Plasma Protein-A / metabolism*
Premature Birth / diagnosis*,  epidemiology,  metabolism*
ROC Curve
Risk Factors
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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