Document Detail


Predictive factors of response to splenectomy in adult chronic idiopathic thrombocytopenic purpura.
MedLine Citation:
PMID:  11325006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 26 surgical patients with chronic idiopathic thrombocytopenic purpura (ITP) were reviewed and results of splenectomy were statistically related to age and sex, length of and response to pre-operative corticosteroid therapy, pre-operative platelet count and time interval between diagnosis and surgery. Median age was 37 years (range, 17-81 years) and the male:female ratio was 1.16. Pre-operative platelet count ranged from 2-70 x 10(9)/l. The length of pre-surgical corticosteroid therapy (prednisone 1-2 mg/kg/day) varied from 2 weeks to 3 years. Steroid therapy was unsuccessful in 15 patients and only achieved temporary remission in the remaining 11 cases. The time interval between diagnosis and splenectomy ranged from 4-60 months. There were 21 responders (80.4%) and 5 non-responders (19.6%) to splenectomy. Using the chi-square test, differences in age, length and response to pre-operative steroid therapy and diagnosis-to-splenectomy interval did not achieve statistical significance when responder and non-responder groups to splenectomy were compared. Conversely, a significant difference was found comparing male to female groups, since 92.9% of males and only 66.7% of females were successfully treated by surgery (P approximately 0.01). In addition, patients with a pre-operative platelet count less than 30 x 10(9)/l responded at an higher rate (100% versus 70.6%; P approximately 0.05) to splenectomy.
Authors:
R Vecchio; E Cacciola; R R Cacciola; E Palazzo; C Rinzivillo; R Giustolisi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International surgery     Volume:  85     ISSN:  0020-8868     ISO Abbreviation:  Int Surg     Publication Date:    2000 Jul-Sep
Date Detail:
Created Date:  2001-04-27     Completed Date:  2001-08-09     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0043524     Medline TA:  Int Surg     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  252-6     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Catania, Italy. rvecchio@mbox.unict.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Platelet Count
Prednisone / administration & dosage
Purpura, Thrombocytopenic, Idiopathic / surgery*
Sex Factors
Splenectomy*
Treatment Outcome
Chemical
Reg. No./Substance:
53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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