Document Detail

Predictive factors for progressive motor deficits in penetrating artery infarctions in two different arterial territories.
MedLine Citation:
PMID:  19836756     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Progressive motor deficits (PMD) are common in cerebral penetrating artery disease (PAD) during the acute stage and leads to severe disability. Reliable predictors and stroke mechanism for PMD in PAD have been yet to be elucidated. Moreover, difference of predictors between topographically classified PAD has not ever been systematically studied. METHODS: Three hundred ninety two consecutive patients with acute PAD (<20 mm) who showed lacunar motor syndrome and admitted within 24 h after onset were selected for this study. Patients were divided into 2 groups whose infarcts were topographically located within the territories of lenticulostriate arteries (LSA), and anterior pontine arteries (APA). Within each of the 2 groups, factors associated with PMD were analyzed. RESULTS: Progressive motor deficits were found in 55 patients (21.0%) in LSA group and 38 patients (29.0%) in APA group. In multivariate analysis, female sex and severity of motor deficit on admission (NIHSS 5 or more) were common independent predictors for PMD in both groups. The specific predictors were single infarcts without concomitant silent lacunar infarcts and preceding TIAs in LSA group and diabetes mellitus in APA group. CONCLUSIONS: Predictive factors for PMD were different in the 2 different territory groups. Diabetes mellitus was particularly associated with PMD in APA group.
Yasumasa Yamamoto; Tomoyuki Ohara; Masashi Hamanaka; Akiko Hosomi; Aiko Tamura; Ichiro Akiguchi; Kotaro Ozasa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  288     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  170-4     Citation Subset:  IM    
Kyoto Second Red Cross Hospital, Kyoto, Japan.
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MeSH Terms
Age Factors
Atherosclerosis / pathology
Cerebral Arteries / pathology*
Cerebral Infarction / complications*,  epidemiology
Cerebrovascular Circulation / physiology
Logistic Models
Magnetic Resonance Imaging
Middle Aged
Movement Disorders / epidemiology,  etiology*
Neostriatum / blood supply
Pons / blood supply
Predictive Value of Tests
Prospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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