| Predictive factors for local recurrence in 2006 patients with surgically resected small breast cancer. | |
| | |
MedLine Citation:
|
PMID: 12196366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Analyses of predictive factors for local recurrences are important, as an increasing number of patients with early breast cancer opt for a breast-conserving procedure. This study investigates whether factors predictive of local recurrence differ between patients treated with conservative or radical surgery. PATIENTS AND METHODS: Two thousands and six patients with invasive breast carcinoma (< or =25 mm) were included. Of these patients, 717 were treated conservatively (lumpectomy and breast irradiation) and 1289 were treated with total mastectomy. All patients had axillary dissection and received lymph node irradiation if axillary nodes were positive. Most patients did not receive adjuvant chemotherapy or additive hormonal treatments. The mean duration of follow-up was 20 years. The main end point was the total local recurrence rate. The risk factors of local recurrence were estimated by multivariate analyses and interaction tests were used for intergroup comparisons. RESULTS: Statistically significant predictive factors for mastectomized patients were histological grade, extensive axillary node involvement (10 nodes or more), and inner quadrant tumors, which were of borderline significance. Young age, however, was not a prognostic indicator for local recurrence. The main statistically significant factor for patients treated with a conservative approach was young age (< or =40 years). These younger patients had a five-fold increased risk of developing a breast recurrence compared with patients older than 60 years. CONCLUSIONS: Younger patients with early breast cancer treated with breast-conserving surgery should in particular be followed up at regular intervals so that any sign of local failure can be diagnosed early. |
| | |
Authors:
|
R Arriagada; M G Lê; G Contesso; J M Guinebretière; F Rochard; M Spielmann |
Related Documents
:
|
7641016 - Treatment trends for ductal carcinoma in situ of the breast. 3129176 - Results of a conservative treatment combining induction (neoadjuvant) and consolidation... 15015706 - The role of clinical trials in changing therapy for ductal carcinoma in situ. 17541936 - Primary angiosarcomas of the breast. 7641016 - Treatment trends for ductal carcinoma in situ of the breast. 21913016 - High serum hyaluronic acid and hbv viral load are main prognostic factors of local recu... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO Volume: 13 ISSN: 0923-7534 ISO Abbreviation: Ann. Oncol. Publication Date: 2002 Sep |
Date Detail:
|
Created Date: 2002-08-28 Completed Date: 2002-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9007735 Medline TA: Ann Oncol Country: England |
Other Details:
|
Languages: eng Pagination: 1404-13 Citation Subset: IM |
Affiliation:
|
Institut Gustave-Roussy (IGR), Villejuif, France. datacenter@gocchi.cl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Distribution Breast Neoplasms / mortality, pathology*, radiotherapy, surgery* Carcinoma, Ductal, Breast / mortality, pathology*, radiotherapy, secondary, surgery* Chile Cohort Studies Combined Modality Therapy Female Humans Incidence Lymph Nodes / pathology* Lymphatic Metastasis Mastectomy / methods Mastectomy, Segmental Multivariate Analysis Neoplasm Recurrence, Local / epidemiology*, pathology* Neoplasm Staging Predictive Value of Tests Probability Prognosis Retrospective Studies Risk Assessment Survival Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: HER-2/neu amplification detected by fluorescence in situ hybridization in fine needle aspirates from...
Next Document: Informing breast cancer patients about clinical trials: a randomized clinical trial of an educationa...