Document Detail

Predictive factors for local recurrence in 2006 patients with surgically resected small breast cancer.
MedLine Citation:
PMID:  12196366     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Analyses of predictive factors for local recurrences are important, as an increasing number of patients with early breast cancer opt for a breast-conserving procedure. This study investigates whether factors predictive of local recurrence differ between patients treated with conservative or radical surgery. PATIENTS AND METHODS: Two thousands and six patients with invasive breast carcinoma (< or =25 mm) were included. Of these patients, 717 were treated conservatively (lumpectomy and breast irradiation) and 1289 were treated with total mastectomy. All patients had axillary dissection and received lymph node irradiation if axillary nodes were positive. Most patients did not receive adjuvant chemotherapy or additive hormonal treatments. The mean duration of follow-up was 20 years. The main end point was the total local recurrence rate. The risk factors of local recurrence were estimated by multivariate analyses and interaction tests were used for intergroup comparisons. RESULTS: Statistically significant predictive factors for mastectomized patients were histological grade, extensive axillary node involvement (10 nodes or more), and inner quadrant tumors, which were of borderline significance. Young age, however, was not a prognostic indicator for local recurrence. The main statistically significant factor for patients treated with a conservative approach was young age (< or =40 years). These younger patients had a five-fold increased risk of developing a breast recurrence compared with patients older than 60 years. CONCLUSIONS: Younger patients with early breast cancer treated with breast-conserving surgery should in particular be followed up at regular intervals so that any sign of local failure can be diagnosed early.
R Arriagada; M G Lê; G Contesso; J M Guinebretière; F Rochard; M Spielmann
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of oncology : official journal of the European Society for Medical Oncology / ESMO     Volume:  13     ISSN:  0923-7534     ISO Abbreviation:  Ann. Oncol.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-28     Completed Date:  2002-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007735     Medline TA:  Ann Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1404-13     Citation Subset:  IM    
Institut Gustave-Roussy (IGR), Villejuif, France.
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MeSH Terms
Age Distribution
Breast Neoplasms / mortality,  pathology*,  radiotherapy,  surgery*
Carcinoma, Ductal, Breast / mortality,  pathology*,  radiotherapy,  secondary,  surgery*
Cohort Studies
Combined Modality Therapy
Lymph Nodes / pathology*
Lymphatic Metastasis
Mastectomy / methods
Mastectomy, Segmental
Multivariate Analysis
Neoplasm Recurrence, Local / epidemiology*,  pathology*
Neoplasm Staging
Predictive Value of Tests
Retrospective Studies
Risk Assessment
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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