| Predictive factors of clinical response in steroid-refractory ulcerative colitis treated with granulocyte-monocyte apheresis. | |
| | |
MedLine Citation:
|
PMID: 21528055 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
AIM: To identify factors predicting the clinical response of ulcerative colitis patients to granulocyte-monocyte apheresis (GMA). METHODS: Sixty-nine ulcerative colitis patients (39 F, 30 M) dependent upon/refractory to steroids were treated with GMA. Steroid dependency, clinical activity index (CAI), C reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), values at baseline, use of immunosuppressant, duration of disease, and age and extent of disease were considered for statistical analysis as predictive factors of clinical response. Univariate and multivariate logistic regression models were used. RESULTS: In the univariate analysis, CAI (P = 0.039) and ESR (P = 0.017) levels at baseline were singled out as predictive of clinical remission. In the multivariate analysis steroid dependency [Odds ratio (OR) = 0.390, 95% Confidence interval (CI): 0.176-0.865, Wald 5.361, P = 0.0160] and low CAI levels at baseline (4 < CAI < 7) (OR = 0.770, 95% CI: 0.425-1.394, Wald 3.747, P = 0.028) proved to be effective as factors predicting clinical response. CONCLUSION: GMA may be a valid therapeutic option for steroid-dependent ulcerative colitis patients with mild-moderate disease and its clinical efficacy seems to persist for 12 mo. |
| | |
Authors:
|
Valeria D'Ovidio; Donatella Meo; Angelo Viscido; Giampaolo Bresci; Piero Vernia; Renzo Caprilli |
Related Documents
:
|
8565165 - Clinical significance of the pulmonary vasodilator response during short-term infusion ... 20327535 - Long-term follow-up of patients with hypertensive disease treated with guanethidine. 1567095 - Glucocorticoid-remediable aldosteronism in a large kindred: clinical spectrum and diagn... 7629485 - Disturbed energy balance in skeletal muscle of patients with untreated primary hyperten... 2781235 - Effects of oral s-adenosyl-l-methionine on hepatic glutathione in patients with liver d... 8081535 - Patient as author, physician as critic. insights from contemporary literary theory. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-04-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
|
Languages: eng Pagination: 1831-5 Citation Subset: IM |
Affiliation:
|
Valeria D'Ovidio, Donatella Meo, Angelo Viscido, Piero Vernia, Renzo Caprilli, Department of Clinical Sciences, Gastrointestinal Unit, Policlinico Umberto I, University of Rome, "La Sapienza", Viale del Policlinico 155, Rome 00161, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Breviscapine attenuates acute pancreatitis by inhibiting expression of PKC? and NF-?B in pancreas.
Next Document: Gastrointestinal stromal tumors: Thirty years experience of an Institution.