Document Detail

Predictive factors for cholangiocarcinoma associated with hepatolithiasis determined on the basis of Japanese Multicenter study.
MedLine Citation:
PMID:  22151748     Owner:  NLM     Status:  PubMed-not-MEDLINE    
AIM:   The aim of this study was to delineate predictive factors for cholangiocarcinoma in patients with hepatolithiasis, and to establish optimal management for hepatolithiasis from the viewpoint of carcinogenesis on the basis of a Japanese nationwide survey for hepatolithiasis.
METHODS:   The Hepatolithiasis Research Group was organized in 2006 by the Ministry of Health, Labour and Welfare of Japan, and conducted a nationwide survey. The research group collected data on 336 cases of hepatolithiasis in 2006, in a cross-sectional survey involving 2592 institutions in Japan. Predictive factors for cholangiocarcinoma associated with hepatolithiasis were analyzed by univariate and multivariate analyses of clinicopathological and therapeutic factors.
RESULTS:   Twenty-three patients had cholangiocarcinoma. Histories of choledocoenterostomy and liver atrophy were found to be significantly predictive factors by multivariate analysis. In 87.5% of cases of cholangiocarcinoma with liver atrophy, cholangiocarcinoma was located in the atrophic lobes. The method of reconstruction did not affect the incidence of cholangiocarcinoma (choledochojejunostomy vs. choledochoduodenostomy; side-to-end vs. side-to-side anastomosis).
CONCLUSIONS:   Choledocoenterostomy and liver atrophy may increase the risk of developing cholangiocarcinoma. Choledocoenterostomy is thus contraindicated in patients with hepatolithiasis. An aggressive resection strategy is recommended for an atrophic segment.
Yutaka Suzuki; Toshiyuki Mori; Nobutsugu Abe; Masanori Sugiyama; Yutaka Atomi
Related Documents :
17056318 - Effectiveness of prehospital wireless transmission of electrocardiograms to a cardiolog...
10871978 - Serum homocysteine concentration as an indicator of survival in patients with acute cor...
18281808 - Reduced coronary flow reserve and parasympathetic dysfunction in patients with cardiova...
8945058 - Effect of transdermal scopolamine on heart rate variability in patients with severe cor...
9316698 - Bromocriptine therapy in multiple sclerosis: an open label pilot study.
18478868 - Choice and responsibility in the nhs.
Publication Detail:
Type:  Journal Article     Date:  2011-12-13
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  42     ISSN:  1386-6346     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-17     Completed Date:  2013-07-04     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  166-70     Citation Subset:  -    
Copyright Information:
© 2011 The Japan Society of Hepatology.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Akt1 deficiency modulates reward learning and reward prediction error in mice.
Next Document:  Overexpression of Id3 induces apoptosis of A549 human lung adenocarcinoma cells.