| Predictive factors affecting early deterioration of axial symptoms after subthalamic nucleus stimulation in Parkinson's disease. | |
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MedLine Citation:
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PMID: 20678955 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment option for medically refractory Parkinson's disease (PD). However, some patients show deterioration of axial symptoms within a short time after surgery. We studied 43 patients who underwent bilateral STN-DBS and investigated predictive factors affecting early deterioration of axial symptoms. Among 43 patients, 16 patients showed obvious deterioration of axial symptoms within three years of surgery. Multiple logistic regression analysis indicated that the significant independent variables related to early deterioration of axial symptoms were rapidly progressive short duration of the disease and advanced age at surgery. These results suggest that patients with rapidly progressing PD, who need early surgical intervention, tend to show early deterioration of axial symptoms after STN-DBS. |
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Authors:
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Atsushi Umemura; Yuichi Oka; Kenji Okita; Takanari Toyoda; Noriyuki Matsukawa; Kazuo Yamada |
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Publication Detail:
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Type: Journal Article Date: 2010-08-03 |
Journal Detail:
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Title: Parkinsonism & related disorders Volume: 16 ISSN: 1873-5126 ISO Abbreviation: Parkinsonism Relat. Disord. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513583 Medline TA: Parkinsonism Relat Disord Country: England |
Other Details:
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Languages: eng Pagination: 582-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Neurosurgery, Nagoya City University Graduate School of Medicine, Mizuho-ku, Nagoya 467-8601, Japan. aume@med.nagoya-cu.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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