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Predictive ability of serum high-molecular-weight adiponectin in combination with serum insulin and serum C-reactive protein for the presence of metabolic syndrome.
MedLine Citation:
PMID:  22324836     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background and aims: Metabolic syndrome (MetS) is an insulin-resistance syndrome deeply associated with obesity. The association between MetS and several clinical factors, including serum levels of adiponectin, C-reactive protein and insulin, was examined. Subjects and methods: The study was performed in 219 men aged 43.2 ± 6.6 years, who were employees of a company. The study measured the serum high sensitivity C-reactive protein (CRP) as an inflammatory marker, serum insulin as a marker of insulin resistance and serum high-molecular-weight adiponectin (HMW-adipo), in addition to the serum levels of liver enzymes and uric acid. MetS was diagnosed according to the National Cholesterol Education Programme ATPIII criteria. Results: Log-transformed serum ALT, HMW-adipo, insulin and uric acid were found to be significantly related to the presence/absence of Mets by logistic regression analysis, with odds ratios (95% confidence intervals) of 25.9 (3.3-204.4), 0.10 (0.02-0.56), 7.5 (1.6-34.1) and 1.5 (1.04-2.1), respectively. Conclusion: Serum high HMW-adipo level was significantly negatively related to the presence of MetS, independently of the serum levels of insulin, liver enzymes and uric acid. Among the markers examined, serum HMW-adipo and ALT were considered as markers for MetS.
Authors:
Tomoyuki Kawada; Miyuki Hasegawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of human biology     Volume:  39     ISSN:  1464-5033     ISO Abbreviation:  Ann. Hum. Biol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404024     Medline TA:  Ann Hum Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  108-12     Citation Subset:  IM    
Affiliation:
Department of Hygiene and Public Health, Nippon Medical School , Tokyo , Japan.
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