Document Detail

Predictive value of serologic markers of degree of histologic damage in acute uncomplicated colonic diverticulitis.
MedLine Citation:
PMID:  20485187     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute uncomplicated diverticulitis (AUD) may show histologic and serologic signs of inflammation.
GOALS: To assess whether serologic markers of inflammation may be predictive of abnormal histology in AUD.
STUDY: Twenty-one consecutive patients affected by AUD were studied (15 Males, 6 Females, mean age 66.19 y, range 43 to 85 y). Diagnosis of AUD was based on specific endoscopic and CT scan patterns. Several serologic markers were assessed [White blood cells (WBC), Erytro-sedimentation Rate, C-reactive protein (CRP), fibrinogen, α1-acid glycoprotein]. Neutrophilic and lymphocytic inflammatory infiltrate was also scored.
RESULTS: WBC was increased in 4/21 pts (19.4%), Erytro-sedimentation Rate in 12/21 pts (57.14%), CRP in 13/21 pts (61.9%), fibrinogen in 5/21 pts (23.8%), and α1-acid glycoprotein in 6/21 pts (28.57%). All serologic markers were related with the degree of histologic damage. In patients scoring 3 in neutrophilic infiltrate (severe active inflammation), all markers showed a statistical significant relation (ranging from P=0.004 for WBC to P=0.00001 for fibrinogen). CRP was the most sensitive marker of mild-moderate histologic damage, as it was increased in 4/10 (40%) patients scoring 0 or 1 in neutrophilic infiltrate (absence of mild active inflammation) (P=0.005).
CONCLUSIONS: Serologic markers showed a strict relation with the degree of histologic damage in AUD. Moreover, CRP is the most sensitive marker of mild-moderate histologic damage.
Antonio Tursi; Walter Elisei; Giovanni Brandimarte; Gian Marco Giorgetti; Fabio Aiello
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  44     ISSN:  1539-2031     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  702-6     Citation Subset:  IM    
Gastroenterology Service, ASL BAT, Andria, Italy.
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MeSH Terms
Acute Disease
Aged, 80 and over
Biological Markers / blood
Blood Sedimentation
C-Reactive Protein / analysis
Colon / immunology*,  pathology*
Diverticulitis, Colonic / blood,  diagnosis*,  immunology,  pathology
Fibrinogen / analysis
Inflammation Mediators / blood*
Leukocyte Count
Lymphocytes / immunology
Middle Aged
Neutrophil Infiltration
Orosomucoid / analysis
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
Severity of Illness Index
Tomography, X-Ray Computed
Reg. No./Substance:
0/Biological Markers; 0/Inflammation Mediators; 0/Orosomucoid; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

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