| Predictive value of serologic markers of degree of histologic damage in acute uncomplicated colonic diverticulitis. | |
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MedLine Citation:
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PMID: 20485187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acute uncomplicated diverticulitis (AUD) may show histologic and serologic signs of inflammation. GOALS: To assess whether serologic markers of inflammation may be predictive of abnormal histology in AUD. STUDY: Twenty-one consecutive patients affected by AUD were studied (15 Males, 6 Females, mean age 66.19 y, range 43 to 85 y). Diagnosis of AUD was based on specific endoscopic and CT scan patterns. Several serologic markers were assessed [White blood cells (WBC), Erytro-sedimentation Rate, C-reactive protein (CRP), fibrinogen, α1-acid glycoprotein]. Neutrophilic and lymphocytic inflammatory infiltrate was also scored. RESULTS: WBC was increased in 4/21 pts (19.4%), Erytro-sedimentation Rate in 12/21 pts (57.14%), CRP in 13/21 pts (61.9%), fibrinogen in 5/21 pts (23.8%), and α1-acid glycoprotein in 6/21 pts (28.57%). All serologic markers were related with the degree of histologic damage. In patients scoring 3 in neutrophilic infiltrate (severe active inflammation), all markers showed a statistical significant relation (ranging from P=0.004 for WBC to P=0.00001 for fibrinogen). CRP was the most sensitive marker of mild-moderate histologic damage, as it was increased in 4/10 (40%) patients scoring 0 or 1 in neutrophilic infiltrate (absence of mild active inflammation) (P=0.005). CONCLUSIONS: Serologic markers showed a strict relation with the degree of histologic damage in AUD. Moreover, CRP is the most sensitive marker of mild-moderate histologic damage. |
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Authors:
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Antonio Tursi; Walter Elisei; Giovanni Brandimarte; Gian Marco Giorgetti; Fabio Aiello |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: 44 ISSN: 1539-2031 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-10-18 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 702-6 Citation Subset: IM |
Affiliation:
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Gastroenterology Service, ASL BAT, Andria, Italy. antotursi@tiscali.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Aged, 80 and over Biological Markers / blood Blood Sedimentation C-Reactive Protein / analysis Colon / immunology*, pathology* Colonoscopy Diverticulitis, Colonic / blood, diagnosis*, immunology, pathology Female Fibrinogen / analysis Humans Inflammation Mediators / blood* Italy Leukocyte Count Lymphocytes / immunology Male Middle Aged Neutrophil Infiltration Orosomucoid / analysis Predictive Value of Tests Prospective Studies Sensitivity and Specificity Severity of Illness Index Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Inflammation Mediators; 0/Orosomucoid; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein |
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