| Predictive value of multislice computed tomography variables of atherosclerosis for ischemia on stress-rest single-photon emission computed tomography. | |
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MedLine Citation:
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PMID: 20660145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: previous studies have shown that the presence of stenosis alone on multislice computed tomography (MSCT) has a limited positive predictive value for the presence of ischemia on myocardial perfusion imaging (MPI). The purpose of this study was to assess which variables of atherosclerosis on MSCT angiography are related to ischemia on MPI. METHODS AND RESULTS: both MSCT and MPI were performed in 514 patients. On MSCT, the calcium score, degree of stenosis (≥ 50% and ≥ 70% stenosis), and plaque extent and location were determined. Plaque composition was classified as noncalcified, mixed, or calcified. Ischemia was defined as a summed difference score (≥ 2 on a per-patient basis. Ischemia was observed in 137 patients (27%). On a per-patient basis, multivariate analysis showed that the degree of stenosis (presence of (≥ 70% stenosis, odds ratio=3.5), plaque extent and composition (mixed plaques (≥3, odds ratio=1.7; calcified plaques ≥ 3, odds ratio=2.0), and location (atherosclerotic disease in the left main coronary artery and/or proximal left anterior descending coronary artery, odds ratio=1.6) were independent predictors for ischemia on MPI. In addition, MSCT variables of atherosclerosis, such as plaque extent, composition, and location, had significant incremental value for the prediction of ischemia over the presence of ≥70% stenosis. CONCLUSIONS: in addition to the degree of stenosis, MSCT variables of atherosclerosis describing plaque extent, composition, and location are predictive of the presence of ischemia on MPI. |
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Authors:
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Joëlla E van Velzen; Joanne D Schuijf; Jacob M van Werkhoven; Bernhard A Herzog; Aju P Pazhenkottil; Eric Boersma; Fleur R de Graaf; Arthur J Scholte; Lucia J Kroft; Albert de Roos; Marcel P Stokkel; J Wouter Jukema; Philipp A Kaufmann; Ernst E van der Wall; Jeroen J Bax |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-21 |
Journal Detail:
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Title: Circulation. Cardiovascular imaging Volume: 3 ISSN: 1942-0080 ISO Abbreviation: Circ Cardiovasc Imaging Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2010-12-23 Revised Date: 2011-09-06 |
Medline Journal Info:
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Nlm Unique ID: 101479935 Medline TA: Circ Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 718-26 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atherosclerosis
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complications,
radiography* Contrast Media / diagnostic use Coronary Angiography / methods Coronary Stenosis / complications, radiography Coronary Vessels / radionuclide imaging Exercise Test / methods* Female Humans Image Enhancement / methods Iopamidol / analogs & derivatives, diagnostic use Male Middle Aged Myocardial Ischemia / complications, radionuclide imaging* Myocardial Perfusion Imaging Odds Ratio Predictive Value of Tests Rest Tomography, Emission-Computed, Single-Photon / methods Tomography, Spiral Computed / methods Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 62883-00-5/Iopamidol; 78649-41-9/iomeprol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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