Document Detail

Predictive Value of Endostatin in Chronic Heart Failure Patients with Poor Kidney Function.
MedLine Citation:
PMID:  25428583     Owner:  NLM     Status:  Publisher    
Objectives: Increased circulating endostatin levels have been demonstrated in progressive cardiovascular (CV) and renal disorders. We investigated the predictive value of endostatin in patients with chronic heart failure (HF) and the association between endostatin and renal function. Methods: The interaction between serum endostatin, estimated glomerular filtration rate (eGFR) and predefined endpoints, including the primary endpoint (CV death, nonfatal myocardial infarction, nonfatal stroke; n = 397), all-cause mortality (n = 410), CV death (n = 335) or the coronary endpoint (n = 317), was evaluated in 1,390 patients >60 years of age with ischemic systolic HF in the Controlled Rosuvastatin Multinational Trial in HF (CORONA) population, who were randomly assigned to 10 mg rosuvastatin or placebo. Results: In the population as a whole, endostatin added no predictive information after full multivariable adjustment including eGFR and N-terminal pro-brain natriuretic peptide. Serum endostatin was strongly correlated with eGFR (r = 0.59, p < 0.001). After full multivariable adjustment, an association between high serum endostatin and increased risk of all-cause mortality and decreased risk of the primary and coronary endpoints was seen in HF patients with impaired and preserved renal function, respectively. Conclusions: Endostatin added no predictive information regarding the adverse outcome in patients with chronic systolic HF of ischemic etiology. An increased risk of all-cause mortality was seen in patients with decreased renal function. © 2014 S. Karger AG, Basel.
Thor Ueland; Pål Aukrust; Ståle H Nymo; John Kjekshus; John J V McMurray; John Wikstrand; Ursula-Henrike Wienhues-Thelen; Dirk Block; Christian Zaugg; Lars Gullestad
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-22
Journal Detail:
Title:  Cardiology     Volume:  130     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-27     Completed Date:  -     Revised Date:  2014-11-28    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  17-22     Citation Subset:  -    
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