Document Detail


Predictive value of an early amplitude integrated electroencephalogram and neurologic examination.
MedLine Citation:
PMID:  21669899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the predictive validity of the amplitude integrated electroencephalogram (aEEG) and stage of encephalopathy among infants with hypoxic-ischemic encephalopathy (HIE) eligible for therapeutic whole-body hypothermia.
DESIGN: Neonates were eligible for this prospective study if moderate or severe HIE occurred at <6 hours and an aEEG was obtained at <9 hours of age. The primary outcome was death or moderate/severe disability at 18 months.
RESULTS: There were 108 infants (71 with moderate HIE and 37 with severe HIE) enrolled in the study. aEEG findings were categorized as normal, with continuous normal voltage (n=12) or discontinuous normal voltage (n=12), or abnormal, with burst suppression (n=22), continuous low voltage (n=26), or flat tracing (n=36). At 18 months, 53 infants (49%) experienced death or disability. Severe HIE and an abnormal aEEG were related to the primary outcome with univariate analysis, whereas severe HIE alone was predictive of outcome with multivariate analysis. Addition of aEEG pattern to HIE stage did not add to the predictive value of the model; the area under the curve changed from 0.72 to 0.75 (P=.19).
CONCLUSIONS: The aEEG background pattern did not significantly enhance the value of the stage of encephalopathy at study entry in predicting death and disability among infants with HIE.
Authors:
Seetha Shankaran; Athina Pappas; Scott A McDonald; Abbot R Laptook; Rebecca Bara; Richard A Ehrenkranz; Jon E Tyson; Ronald Goldberg; Edward F Donovan; Avroy A Fanaroff; Abhik Das; W Kenneth Poole; Michele Walsh; Rosemary D Higgins; Cherie Welsh; Walid Salhab; Waldemar A Carlo; Brenda Poindexter; Barbara J Stoll; Ronnie Guillet; Neil N Finer; David K Stevenson; Charles R Bauer;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-06-13
Journal Detail:
Title:  Pediatrics     Volume:  128     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-04     Completed Date:  2011-09-01     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e112-20     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 by the American Academy of Pediatrics.
Affiliation:
Department of Pediatrics, Wayne State University, Detroit, Michigan, USA. sshankar@med.wayne.edu
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MeSH Terms
Descriptor/Qualifier:
Electroencephalography*
Female
Follow-Up Studies
Humans
Hypoxia-Ischemia, Brain / diagnosis*
Infant, Newborn
Male
Neurologic Examination*
Predictive Value of Tests
Prospective Studies
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
M01 RR16587/RR/NCRR NIH HHS; M01 RR30/RR/NCRR NIH HHS; M01 RR32/RR/NCRR NIH HHS; M01 RR39/RR/NCRR NIH HHS; M01 RR44/RR/NCRR NIH HHS; M01 RR6022/RR/NCRR NIH HHS; M01 RR633/RR/NCRR NIH HHS; M01 RR70/RR/NCRR NIH HHS; M01 RR7122/RR/NCRR NIH HHS; M01 RR750/RR/NCRR NIH HHS; M01 RR80/RR/NCRR NIH HHS; M01 RR8084/RR/NCRR NIH HHS; U01 HD36790/HD/NICHD NIH HHS; U10 HD21364/HD/NICHD NIH HHS; U10 HD21373/HD/NICHD NIH HHS; U10 HD21385/HD/NICHD NIH HHS; U10 HD21397/HD/NICHD NIH HHS; U10 HD27851/HD/NICHD NIH HHS; U10 HD27853/HD/NICHD NIH HHS; U10 HD27856/HD/NICHD NIH HHS; U10 HD27871/HD/NICHD NIH HHS; U10 HD27880/HD/NICHD NIH HHS; U10 HD27904/HD/NICHD NIH HHS; U10 HD34216/HD/NICHD NIH HHS; U10 HD40461/HD/NICHD NIH HHS; U10 HD40492/HD/NICHD NIH HHS; U10 HD40498/HD/NICHD NIH HHS; U10 HD40521/HD/NICHD NIH HHS; U10 HD40689/HD/NICHD NIH HHS; UL1 RR24139/RR/NCRR NIH HHS; UL1 RR25008/RR/NCRR NIH HHS
Investigator
Investigator/Affiliation:
Alan H Jobe / ; Michael S Caplan / ; William Oh / ; Betty R Vohr / ; Angelita Hensman / ; Theresa M Leach / ; Victoria E Watson / ; Suzy Ventura / ; Deanne Wilson-Costello / ; Nancy S Newman / ; Bonnie S Siner / ; Kurt Schibler / ; Jean Steichen / ; Kimberly Yolton / ; Barb Alexander / ; Cathy Grisby / ; Marcia Mersmann / ; Holly Mincey / ; Jody Shively / ; Teresa Gratton / ; C Michael Cotten / ; Ricki Goldstein / ; Kathy J Auten / ; Kimberly A Fisher / ; Melody B Lohmeyer / ; Ira Adams-Chapman / ; David Carlton / ; Lucky Jain / ; Ellen Hale / ; Linda L Wright / ; Elizabeth M McClure / ; Stephanie Wilson Archer / ; James A Lemons / ; Anna M Dusick / ; Diana D Appel / ; Dianne Herron / ; Lucy Miller / ; Leslie Richard / ; Leslie Dawn Wilson / ; Margaret Cunningham / ; Betty Hastings / ; Elizabeth McClure / ; Jamie Newman / ; Rebecca L Perritt / ; Carolyn Petrie Huitema / ; Kristin Zaterka-Baxter / ; David K Stevenson / ; Krisa P Van Meurs / ; Susan R Hintz / ; M Bethany Ball / ; Myriam Peralta-Carcelen / ; Monica V Collins / ; Shirley S Cosby / ; Vivien Phillips / ; San Diego / ; Yvonne E Vaucher / ; Maynard R Rasmussen / ; David Kaegi / ; Kathy Arnell / ; Clarence Demetrio / ; Martha G Fuller / ; Chris Henderson / ; Wade Rich / ; Shahnaz Duara / ; Charles R Bauer / ; Sylvia Hiriart-Fajardo / ; Silvia M Frade Eguaras / ; Ruth Everett / ; Susan Gauthier / ; Kasey Hamlin-Smith / ; Michelle Harwood / ; Ronnie Guillet / ; Gary J Myers / ; Erica Burnell / ; Diane Hust / ; Rosemary L Jensen / ; Joan Merzbach / ; Linda J Reubens / ; Mary Rowan / ; Kelly Yost / ; Lauren Zwetsch / ; Abbot R Laptook / ; Charles R Rosenfeld / ; Pablo J Sánchez / ; R Sue Broyles / ; Roy J Heyne / ; Susie Madison / ; Jackie F Hickman / ; Gaynelle Hensley / ; Nancy A Miller / ; Janet Morgan / ; Jon E Tyson / ; Kathleen A Kennedy / ; Brenda H Morris / ; Pamela J Bradt / ; Patricia W Evans / ; Esther G Akpa / ; Patty A Cluff / ; Susan Dieterich / ; Claudia Y Franco / ; Terri Major-Kincade / ; Robert E Lasky / ; Anna E Lis / ; Georgia McDavid / ; Nehal A Parikh / ; Margaret L Poundstone / ; Sharon L Wright / ; Laura L Whitely / ; T Michael O'Shea / ; Robert G Dillard / ; Lisa Washburn / ; Nancy Peters / ; Barbara Jackson / ; Athina Pappas / ; Yvette Johnson / ; Geraldine Muran / ; Debbie Kennedy / ; Patricia Gettner / ; Monica Konstantino / ; JoAnn Poulsen / ; Elaine Romano / ; Janet Taft / ; Joanne Williams /
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