Document Detail

Predictions of serum vancomycin concentrations by means of six different equations for calculation of creatinine clearance.
MedLine Citation:
PMID:  9403347     Owner:  NLM     Status:  MEDLINE    
Serum vancomycin concentrations were predicted in 59 patients by means of the PKS programme using six different equations to calculate creatinine clearance. These equations are (i) Chiou & Hsu equation, (ii) Cockroft-Gault lean body-weight equation, (iii) Cockroft-Gault total body-weight equation, (iv) Jelliffe equation, (v) Jelliffe & Jelliffe equation, and (vi) Siersback-Neilsen equation. The predictions were made by using (i) the implemented population pharmacokinetic parameters (IPPP), and (ii) the Bayesian method (BM). The results show that (i) if IPPP can lead to under-predictions, and Chiou & Hsu equation is most suited for predictions, and (ii) if IPPP can lead to over-predictions, the Cockroft-Gault total body-weight equation is the most suited for predictions.
G Wu; M Furlanut
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology research     Volume:  17     ISSN:  0251-1649     ISO Abbreviation:  Int J Clin Pharmacol Res     Publication Date:  1997  
Date Detail:
Created Date:  1998-01-27     Completed Date:  1998-01-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8110183     Medline TA:  Int J Clin Pharmacol Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Institute of Clinical Pharmacology and Toxicology, University of Udine, Italy.
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MeSH Terms
Analysis of Variance
Anti-Bacterial Agents / blood*,  pharmacokinetics
Body Weight
Creatinine / urine*
Models, Biological
Predictive Value of Tests
Vancomycin / blood*,  pharmacokinetics
Reg. No./Substance:
0/Anti-Bacterial Agents; 1404-90-6/Vancomycin; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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