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Prediction of transplant-related complications by C-reactive protein levels before hematopoietic SCT.
MedLine Citation:
PMID:  23042494     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Various biomarkers have been investigated with regard to their ability to predict the outcome of allogeneic hematopoietic SCT (HSCT). In this study, we retrospectively reviewed 90 recipients who received HSCT between 2007 and 2011 in our institution, and evaluated the predictive value of the baseline serum C-reactive protein (CRP) levels just before the initiation of conditioning for transplant-related complications after allogeneic HSCT. A receiver-operating characteristic curve revealed that the baseline serum CRP levels had an excellent predictive value for non-relapse mortality (NRM), with an area under the curve of 0.83. The sensitivity and specificity for NRM were 80% and 87%, respectively, with a cutoff of 0.6 mg/dL. With this cutoff value, multivariate analyses revealed that a higher baseline CRP level was an independent risk factor for NRM (HR 6.21, P<0.01), grade III-IV acute GVHD (HR 3.91, P=0.03) and poor overall survival (HR 3.27, P=0.0018). On the other hand, the baseline CRP level did not predict infectious events. These findings suggested that CRP levels before conditioning may be a useful predictive biomarker for poor survival.Bone Marrow Transplantation advance online publication, 8 October 2012; doi:10.1038/bmt.2012.193.
Authors:
M Sato; H Nakasone; K Oshima; Y Ishihara; H Wada; K Sakamoto; K Kawamura; M Ashizawa; T Machishima; K Terasako; S Kimura; M Kikuchi; S Okuda; A Tanihara; R Yamazaki; Y Tanaka; J Kanda; S Kako; J Nishida; Y Kanda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-08
Journal Detail:
Title:  Bone marrow transplantation     Volume:  -     ISSN:  1476-5365     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
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