Document Detail


Prediction of therapeutic strategy and outcome for antenatally diagnosed pulmonary atresia/stenosis with intact ventricular septum.
MedLine Citation:
PMID:  18724024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The therapeutic strategy for pulmonary atresia (PA) and severe pulmonary stenosis (PS) with intact ventricular septum is controversial. Recent improvements in prenatal detection necessitate the identification of predictors of outcome for appropriate counseling and prenatal management planning. METHODS AND RESULTS: Echocardiograms of 18 fetuses antenatally diagnosed with PA (n=14) and PS (n=4) were reviewed and the total cardiac dimension (TCD) and tricuspid valve diameter (TVD) were measured. The right ventricular end-diastolic volume (RVEDV) was calculated from the right ventriculogram of the neonatal period by the percentage of the predicted normal value (%RVEDV). There was a positive correlation between TVD/TCD and %RVEDV (p<0.001). As the initial treatment, balloon atrioseptostomy was performed in 13 cases of TVD/TCD<0.26. As the final treatment, patients with TVD/TCD<0.17 underwent or were planned for the Fontan procedure. Patients with TVD/TCD>0.21 underwent or were planned for biventricular repair. Patients whose TVD/TCD was between 0.17 and 0.21 underwent or were planned for 1.5 ventricular repairs. CONCLUSION: TVD/TCD is a useful index for selecting the postnatal initial treatment for PA/PS and to predict the final status of the fetus. Prenatal detection and prediction of the future status is helpful for family counseling. Furthermore, it will help to decide the postnatal management prenatally.
Authors:
Yukiko Kawazu; Noboru Inamura; Futoshi Kayatani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2009-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1471-5     Citation Subset:  IM    
Affiliation:
Department of Pediatric Cardiology, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan. kadoy@mch.pref.osaka.jp
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MeSH Terms
Descriptor/Qualifier:
Balloon Dilatation
Constriction, Pathologic / therapy,  ultrasonography
Female
Fetal Diseases / therapy*,  ultrasonography*
Fetus*
Humans
Male
Pulmonary Atresia / therapy*,  ultrasonography*
Retrospective Studies
Treatment Outcome
Tricuspid Valve / ultrasonography
Ultrasonography, Prenatal*
Ventricular Septum / ultrasonography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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