| Prediction of suboptimal primary cytoreduction in primary ovarian cancer with combined positron emission tomography/computed tomography--a prospective study. | |
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MedLine Citation:
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PMID: 18055006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To prospectively identify combined PET/CT predictors of incomplete/suboptimal primary cytoreduction in advanced ovarian cancer. METHODS: From September 2004 to March 2007, 179 patients with a Risk of Malignancy Index (RMI) >150 based on serum CA-125, ultrasound examinations and menopausal state, underwent PET/CT within 2 weeks prior to standard surgery/debulking of a pelvic tumor. Ten PET/CT features were identified and evaluated as predictors of cytoreduction in 54 patients with advanced ovarian cancer. RESULTS: Complete cytoreduction (no macroscopic residual disease) was achieved in 35% and optimal cytoreduction (<1 cm residual disease) was achieved in 56%. Using univariate analysis, predictors of incomplete cytoreduction were large bowel mesentery implants (LBMI) (P<0.003), pleural effusion (P<0.009), ascites (P<0.009) and peritoneal carcinosis (P<0.01). LBMI (P<0.03) and ascites (P<0.05) were also predictors of suboptimal cytoreduction. Using multivariate analysis, LBMI was the only independent predictor of incomplete cytoreduction (P=0.004) and no predictor of suboptimal cytoreduction was found. CONCLUSION: PET/CT predictors of cytoreduction were found. But they should not be used to withhold patients form primary cytoreductive surgery. We suggest PET/CT as a supplementary image modality prior to surgery in primary OC patients whenever accurate and comprehensive preoperative evaluation of primary tumor and metastases is desired. |
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Authors:
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S Risum; C Høgdall; A Loft; A K Berthelsen; E Høgdall; L Nedergaard; L Lundvall; S A Engelholm |
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Publication Detail:
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Type: Journal Article Date: 2007-12-04 |
Journal Detail:
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Title: Gynecologic oncology Volume: 108 ISSN: 1095-6859 ISO Abbreviation: Gynecol. Oncol. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-05 Completed Date: 2008-02-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 265-70 Citation Subset: IM |
Affiliation:
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Department of Oncology, The Finsen Center, Rigshospitalet, Copenhagen University Hospital, Denmark. signerisum@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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diagnosis*,
pathology,
radionuclide imaging,
surgery* Adult Aged Aged, 80 and over Female Fluorodeoxyglucose F18 / diagnostic use Humans Middle Aged Neoplasm Staging Ovarian Neoplasms / diagnosis*, pathology, radionuclide imaging, surgery* Positron-Emission Tomography Predictive Value of Tests Prospective Studies Radiopharmaceuticals / diagnostic use Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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