Document Detail

Prediction of severe adverse reactions to ionic and nonionic contrast media in Japan: evaluation of pretesting. A report from the Japanese Committee on the Safety of Contrast Media.
MedLine Citation:
PMID:  1987594     Owner:  NLM     Status:  MEDLINE    
In a nationwide prospective study of adverse reactions to intravenous contrast media (CM), the Japanese Committee on the Safety of Contrast Media compared high-osmolar ionic CM with low-osmolar nonionic CM. A total of 337,647 cases were analyzed. The reliability of pretesting with an intravenous injection of a small amount of CM as a means of predicting severe or fatal reactions was also evaluated. The predictive values of the pretest were 1.2% for ionic and 0.0% for nonionic CM, and the sensitivity values were 3.7% and 0.0%, respectively. Such low values render this test meaningless for predicting which patients are at risk of a severe adverse reaction. A comparison of the incidence of severe adverse reactions between the nonpretested and pretested patients, as well as between the nonpretested and pretested patients with negative results, disclosed no statistically significant differences. Also, no beneficial effects of premedication in patients with a positive pretest were proved. The authors therefore conclude that pretesting with an intravenous injection of a small amount of CM is not useful in predicting severe reactions to ionic or nonionic CM.
K Yamaguchi; H Katayama; T Takashima; T Kozuka; P Seez; K Matsuura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Radiology     Volume:  178     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-02-20     Completed Date:  1991-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  363-7     Citation Subset:  AIM; IM    
Department of Radiology, Yamagata University, Japan.
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MeSH Terms
Contrast Media / administration & dosage,  adverse effects*
Drug Hypersensitivity / diagnosis*,  etiology,  prevention & control
Injections, Intravenous
Osmolar Concentration
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
Reg. No./Substance:
0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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