Document Detail


Prediction of severe adverse drug reactions using pharmacogenetic biomarkers.
MedLine Citation:
PMID:  20460818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Severe adverse drug reactions (ADRs) are a major issue for drug therapy because they can cause serious disorders and be life-threatening. Many severe ADRs appear to be idiosyncratic and unpredictable. Genetic factors may underlie susceptibility to severe ADRs, and identification of predisposing genotypes may improve drug therapy by facilitating prescreening of carriers for specific genetic biomarkers. In this review, we clarify the current status of ADRs in Japan from open ADR data sources. Then, we introduce recent progress in the field of pharmacogenetic biomarkers for severe cutaneous ADRs, liver injury, and statin-induced myopathy. Key challenges for discovery of predictable risk alleles for these severe ADRs are also discussed.
Authors:
Masahiro Tohkin; Akihiro Ishiguro; Nahoko Kaniwa; Yoshiro Saito; Kouichi Kurose; Ryuichi Hasegawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug metabolism and pharmacokinetics     Volume:  25     ISSN:  1880-0920     ISO Abbreviation:  Drug Metab. Pharmacokinet.     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-12     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101164773     Medline TA:  Drug Metab Pharmacokinet     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  122-33     Citation Subset:  IM    
Affiliation:
National Institute of Health Sciences, Tokyo, Japan. tohkin@nihs.go.jp
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD98 / adverse effects
Biological Markers / analysis*
Drug Monitoring
Drug Toxicity / diagnosis*
Drug-Induced Liver Injury
Epidermal Necrolysis, Toxic / etiology
Genetic Markers / genetics*
Humans
Japan
Muscular Diseases / chemically induced
Pharmaceutical Preparations / adverse effects*
Pharmacogenetics / methods*
Stevens-Johnson Syndrome / chemically induced
Chemical
Reg. No./Substance:
0/Antigens, CD98; 0/Biological Markers; 0/Genetic Markers; 0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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