Document Detail

Prediction of response to sodium intervention for blood pressure control.
MedLine Citation:
PMID:  3553478     Owner:  NLM     Status:  MEDLINE    
In the Dietary Intervention Study of Hypertension (DISH) we found that patients formerly treated with drugs and assigned to sodium-reduction intervention were twice as likely to remain off medication for up to 56 weeks as were the controls assigned to no-diet intervention, after adjusting for covariates. Within the sodium-restriction group approximately 60% of 131 people were Intervention Successes (IS) (urinary sodium less than or equal to 100 mmol/day at 8 weeks). The rest were classed as Non-Intervention Successes (NIS). Of the IS group, 54% were responders (drug-free for at least 56 weeks), but about 56% of the NIS group also remained drug-free. Multiple logistics showed that no one factor was able to predict response among the IS. We conclude that the IS likely to respond to sodium reduction are not readily identifiable a priori. Furthermore, since both IS and NIS showed similar blood-pressure effects from the sodium-restriction regimen compared with controls, the questions arise: whether a factor other than sodium reduction affects the blood pressure response for the sodium-restriction group; or whether the measurement of sodium intake and excretion is sufficiently precise to distinguish compliers from non-compliers.
S Wassertheil-Smoller; M D Blaufox; H G Langford; A Oberman; G Cutter; S Pressel
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  4     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-06-05     Completed Date:  1987-06-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S343-6     Citation Subset:  IM    
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MeSH Terms
Antihypertensive Agents / therapeutic use
Clinical Trials as Topic
Diet, Sodium-Restricted*
Hypertension / diet therapy*,  drug therapy
Random Allocation
Grant Support
Reg. No./Substance:
0/Antihypertensive Agents

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