| Prediction of response to definitive chemoradiotherapy in esophageal cancer using positron emission tomography. | |
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MedLine Citation:
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PMID: 17695425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Positron emission tomography (PET) with 18-F-fluorodeoxyglucose (FDG) has already proven useful in assessing the extension of esophageal carcinomas, detecting tumor recurrence and monitoring responses to therapy. The current study aims to assess the potential role of FDG-PET in predicting the response of esophageal squamous cell carcinoma (SCC) to definitive chemoradiotherapy (CRT). PATIENTS AND METHODS: Twenty-seven patients with thoracic esophageal SCC who received definitive CRT between January 2001 and December 2005 underwent PET before and after CRT. The clinical evaluation of the primary tumor response to treatment was classified as either complete response (CR) or non-CR. RESULTS: All patients had intensive FDG uptake in the primary tumor prior to CRT. The standardized uptake value (SUV) averaged 8.2+/-4.7 before CRT and decreased significantly to 2.8+/-1.8 after CRT (p<0.0001). The SUV before CRT averaged 10.2 in the non-CR group (n=17) and 4.9 in the CR group (n= 10). The SUV after CRT averaged 3.7 in the non-CR group and 1.4 in the CR group. The change in SUV for the CR group was higher than that in the non-CR group (p<0.05). The relationship between clinical features and clinical CR was analyzed using logistic regression analysis which revealed significant correlations between clinical CR and the longitudinal dimension of the tumor (p <0.05), SUV before CRT (p<0.05), SUV after CRT (p<0.01) and tumor classification (p <0.05). If the clinical features before CRT were limited, multivariate analysis revealed that the SUV before CRT was an independent predictor for clinical CR (p<0.05). CONCLUSION: In predicting clinical evaluation of therapy prior to CRT, we suggest that SUV prior to definitive CRT is one of the most reliable predictors of response, along with tumor dimensions and classification. |
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Authors:
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Hiroyuki Kato; Minoru Fukuchi; Tatsuya Miyazaki; Masanobu Nakajima; Naritaka Tanaka; Takanori Inose; Hitoshi Kimura; Ahmad Faried; Kana Saito; Makoto Sohda; Yasuyuki Fukai; Norihiro Masuda; Ryokuhei Manda; Hitoshi Ojima; Katsuhiko Tsukada; Noboru Oriuchi; Keigo Endo; Tetsuo Nonaka; Mariko Shioya; Hitoshi Ishikawa; Hideyuki Sakurai; Takashi Nakano; Hiroyuki Kuwano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 27 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2007 Jul-Aug |
Date Detail:
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Created Date: 2007-08-15 Completed Date: 2007-08-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 2627-33 Citation Subset: IM |
Affiliation:
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Departments of General Surgical Science (Surgery I), Gunma University, Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi 371-8511, Japan. hiroyuki@po.wind.ne.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Squamous Cell / drug therapy, radionuclide imaging*, radiotherapy, therapy* Esophageal Neoplasms / drug therapy, radionuclide imaging*, radiotherapy, therapy* Female Fluorine Radioisotopes / diagnostic use Fluorodeoxyglucose F18 / diagnostic use Humans Male Middle Aged Positron-Emission Tomography / methods Predictive Value of Tests Radiopharmaceuticals / diagnostic use Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Fluorine Radioisotopes; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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