| Prediction of response of chronic depression to imipramine. | |
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MedLine Citation:
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PMID: 2529294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We had previously reported that imipramine was superior to placebo for the treatment of chronic depression. As a part of that study, we subsequently investigated clinical and demographic variables which might be associated with favorable or poor outcome for treatment with imipramine or placebo. Results are reported herein. Eight-six patients were entered and 53 completed an 8-week protocol. Outcome was assessed based on a 6-week, double-blind treatment phase, which followed a 2-week, single-blind placebo phase. Outcome was not found to significantly relate to demographic variables, severity or course of depression, diagnostic subtype, symptom profile, or DST results. Some modest associations were found between 'neurotic' personality traits and poor outcome. Results are discussed and compared with prior studies of prediction of tricyclic antidepressant response in both acute and chronic depressions. |
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Authors:
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J H Kocsis; B J Mason; A J Frances; J Sweeney; J J Mann; D Marin |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of affective disorders Volume: 17 ISSN: 0165-0327 ISO Abbreviation: J Affect Disord Publication Date: 1989 Nov-Dec |
Date Detail:
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Created Date: 1989-11-01 Completed Date: 1989-11-01 Revised Date: 2009-09-28 |
Medline Journal Info:
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Nlm Unique ID: 7906073 Medline TA: J Affect Disord Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 255-60 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, New York Hospital-Cornell Medical Center, NY 10021. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chronic Disease Depressive Disorder / drug therapy*, psychology Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Humans Imipramine / administration & dosage, therapeutic use* Male Middle Aged Psychiatric Status Rating Scales Randomized Controlled Trials as Topic |
| Grant Support | |
ID/Acronym/Agency:
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5 MOI-RR00047/RR/NCRR NIH HHS; MH 37103/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-49-7/Imipramine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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