Document Detail

Prediction of response of chronic depression to imipramine.
MedLine Citation:
PMID:  2529294     Owner:  NLM     Status:  MEDLINE    
We had previously reported that imipramine was superior to placebo for the treatment of chronic depression. As a part of that study, we subsequently investigated clinical and demographic variables which might be associated with favorable or poor outcome for treatment with imipramine or placebo. Results are reported herein. Eight-six patients were entered and 53 completed an 8-week protocol. Outcome was assessed based on a 6-week, double-blind treatment phase, which followed a 2-week, single-blind placebo phase. Outcome was not found to significantly relate to demographic variables, severity or course of depression, diagnostic subtype, symptom profile, or DST results. Some modest associations were found between 'neurotic' personality traits and poor outcome. Results are discussed and compared with prior studies of prediction of tricyclic antidepressant response in both acute and chronic depressions.
J H Kocsis; B J Mason; A J Frances; J Sweeney; J J Mann; D Marin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of affective disorders     Volume:  17     ISSN:  0165-0327     ISO Abbreviation:  J Affect Disord     Publication Date:    1989 Nov-Dec
Date Detail:
Created Date:  1989-11-01     Completed Date:  1989-11-01     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  IM    
Department of Psychiatry, New York Hospital-Cornell Medical Center, NY 10021.
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MeSH Terms
Chronic Disease
Depressive Disorder / drug therapy*,  psychology
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Imipramine / administration & dosage,  therapeutic use*
Middle Aged
Psychiatric Status Rating Scales
Randomized Controlled Trials as Topic
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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