| Prediction of respiratory distress syndrome using the Abbott FLM-II amniotic fluid assay. | |
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MedLine Citation:
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PMID: 12417097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Most laboratories using the Abbott FLM-II assay for assessing fetal lung maturity follow the manufacturer's recommendations for interpreting the surfactant to albumin ratio (S/A). Thus, values >55 mg/g are considered mature and values <40 mg/g, immature-leaving a wide range of indeterminate values. Little data is available to assist the clinician in interpreting values between 40 and 55 mg/g. The goal of this study was to determine decision levels that would more clearly identify risk for RDS based on S/A results. METHODS: Respiratory distress syndrome was identified based on medical record review in 46 infants (born at six hospitals), who had S/A measurements on amniotic fluid within 72 h of delivery. An additional 257 women, who had had the S/A test requested but had non-RDS infants, were also identified for this study. The probability of RDS was calculated based on S/A values and on gestational age. Odds ratios were computed for different S/A ratios and different gestational ages. RESULTS: Probability of RDS increased with decreasing S/A and decreasing gestational age. At gestational age >36 weeks, the probability of developing RDS ranged from 1% at S/A>44 mg/g to 39% at S/A</=20 mg/g. At gestational age <34, the probability of developing RDS ranged from 14% at S/A>44 mg/g to 92% at S/A</=20 mg/g. CONCLUSIONS: We report a risk-based approach for the clinical interpretation of the results of Abbott FLM-II assays based on a broad range of S/A values and gestational ages. |
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Authors:
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Lawrence A Kaplan; John F Chapman; Jay L Bock; Edward Santa Maria; Sanda Clejan; David J Huddleston; Roberta G Reed; Larry H Bernstein; Jonathan Gillen-Goldstein |
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Publication Detail:
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Type: Comment; Journal Article; Review |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 326 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-05 Completed Date: 2003-06-16 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 61-8 Citation Subset: IM |
Affiliation:
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Bellevue Hospital, Department of Pathology, New York University, New York, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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analysis* Amniotic Fluid / chemistry Female Fetal Organ Maturity Gestational Age Humans Infant, Newborn Lung / embryology* Predictive Value of Tests Pregnancy Pulmonary Surfactants / analysis* Respiratory Distress Syndrome, Newborn / diagnosis*, epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Pulmonary Surfactants |
| Comments/Corrections | |
Comment On:
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Clin Chim Acta. 2002 Dec;326(1-2):1-2
[PMID:
12417093
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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