| Prediction of regional myocardial blood flow in dogs. | |
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MedLine Citation:
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PMID: 7435578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three indices of regional coronary flow were tested to determine if a good correlation between calculated driving pressure and flow could be found. Four different myocardial depths were examined. All three indexes were based on subtraction of a backpressure to flow. The first assumed backpressure to be equal to ventricular pressure; the second assumed backpressure to be twice ventricular pressure; and the third index assumed backpressure to be zero and thus was simply coronary pressure. Only the index that used left ventricular pressure as the backpressure to flow exhibited proportionality for the subendocardial samples. Similarly, only coronary pressure yielded a good fit for the subepicardial samples. Although subendocardial flow was always in proportion to the index, the index was poor at predicting the absolute value of that flow. The usefulness of such a directional predictor of subendocardial perfusion was illustrated by examining the phase shift resulting from partial occlusion of a coronary artery. The index predicted that subendocardial flow would be lower when coronary pressure was reduced by partially occluding the coronary vessel than when it was presented with an equivalent steady pressure. Microsphere measurements confirmed this prediction. We conclude that an index that assumes ventricular pressure to be the backpressure to flow is an accurate predictor of relative changes in subendocardial perfusion. |
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Authors:
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D F Munch; J M Downey |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 239 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1980 Sep |
Date Detail:
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Created Date: 1981-01-26 Completed Date: 1981-01-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H308-15 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure* Cesium Radioisotopes / diagnostic use Chromium Radioisotopes / diagnostic use Coronary Circulation* Dogs / physiology* Endocardium / physiology Female Male Microspheres Reference Values Regional Blood Flow* Strontium / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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HL-20648/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cesium Radioisotopes; 0/Chromium Radioisotopes; 7440-24-6/Strontium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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