Document Detail


Prediction of recurrent venous thromboembolism by measuring ProC Global.
MedLine Citation:
PMID:  18064319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In patients with venous thromboembolism (VTE) a laboratory assay that globally measures the overall thrombophilic tendency is not available. We hypothesized that determination of ProC((R)) Global, a plasma assay which tests the global function of the protein C pathway, could be used to stratify patients according to their risk of recurrent VTE. We prospectively followed 774 patients with first spontaneousVTE for a mean time of 52 months. ProC Global normalized ratio (NR) was measured in plasma by use of a commercially available assay based on activated partial thromboplastin time. Ninety-eight of the 774 patients had recurrentVTE. Patients with ProC Global NR > or = 0.75 had a relative risk of recurrence of 0.59 (95% CI 0.40-0.87) as compared with those with lower ratio. After four years, cumulative probability of recurrence was 8.6% in patients with ProC Global NR > or = 0.75 and 17.4% in patients with a lower ratio (p = 0.006). Patients with a high ProC Global NR have a low risk of recurrent VTE. ProC Global NR can be used to stratify patients with a first unprovoked VTE according to their risk of recurrence.
Authors:
Sabine Eichinger; Gregor Hron; Mirko Hirschl; Christine Bialonczyk; Erich Minar; Marietta Kollars; Paul A Kyrle
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  98     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-07     Completed Date:  2008-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1232-6     Citation Subset:  IM    
Affiliation:
Dept. of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. sabine.eichinger@meduniwien.ac.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticoagulants / therapeutic use
Austria
Female
Follow-Up Studies
Humans
Male
Middle Aged
Odds Ratio
Partial Thromboplastin Time*
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
Protein C / metabolism*
Reagent Kits, Diagnostic*
Recurrence
Risk Assessment
Sensitivity and Specificity
Time Factors
Venous Thromboembolism / blood,  diagnosis*,  etiology,  prevention & control
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Protein C; 0/Reagent Kits, Diagnostic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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