Document Detail

Prediction of progression of radiographic knee osteoarthritis using tibial trabecular bone texture.
MedLine Citation:
PMID:  21989629     Owner:  NLM     Status:  Publisher    
OBJECTIVE.: To develop a system for prediction of progression of radiographic knee osteoarthritis (OA) using tibial trabecular bone (TB) texture. METHODS.: We studied 203 knees with (n=68) or without (n=135) radiographic tibiofemoral OA in 105 subjects (90 men, 15 women, mean age 54 years) who had 2 sets of knee radiographs taken 4 years apart. We determined medial and lateral compartment tibial TB texture using an automated region selection method. Three texture parameters were calculated: roughness, degree of anisotropy, and direction of anisotropy based on a signature dissimilarity measure method. We evaluated tibiofemoral OA progression using a radiographic semi-quantitative outcome: an increase in the medial joint space narrowing (JSN) grade. We examined the predictive ability of TB texture in knees with and without pre-existing radiographic OA, with adjustment for age, sex, and body mass index using logistic regression (generalized estimating equations) and receiver operating characteristic curves. RESULTS.: The prediction of increased medial JSN in knees with or without pre-existing radiographic OA was the most accurate for medial TB texture; area under the curve (AUC) was 0.77 and 0.75, respectively. For lateral TB texture, AUC was 0.71 and 0.72, respectively. CONCLUSION.: We have developed a system, based on analyzing tibial TB texture, which yields good prediction of loss of tibiofemoral joint space. The predictive ability of the system needs to be further validated. © 2011 American College of Rheumatology.
T Woloszynski; P Podsiadlo; G W Stachowiak; M Kurzynski; L S Lohmander; M Englund
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-11
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  -     ISSN:  1529-0131     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 by the American College of Rheumatology.
School of Mechanical and Chemical Engineering, University of Western Australia, Crawley, Perth, Western Australia.
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