Document Detail

Prediction of preterm delivery using changes in serum relaxin in low risk pregnancies.
MedLine Citation:
PMID:  16337329     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine serum relaxin as a predictor of spontaneous preterm delivery. STUDY DESIGN: A prospective study of 2846 women with singleton pregnancies, from which a matched case-control study (84 cases of spontaneous preterm delivery before 37 weeks gestation and 175 controls) and a cohort (84 preterm and 399 term deliveries) were extracted. RESULTS: In the women with a subsequent preterm delivery the relaxin level decreased by 0.9% per week as compared to 1.9% per week (t-test, p=0.004) in the women with term deliveries. From the cohort the course of S-relaxin during pregnancy in both preterm and term deliveries were fitted and graphed. S-relaxin level was raised in women who were hormonally stimulated to obtain pregnancy (p=0.0001), and lower in women with pre-pregnancy overweight (BMI> or =25, p=0.01) as well as in women, who had previously been pregnant (p=0.008). A longitudinal adjusted model for the prediction of preterm delivery based on the change in S-relaxin was established. CONCLUSIONS: S-relaxin levels decrease less rapidly in women who subsequently deliver preterm; this results in elevated S-relaxin levels in the second and the third trimesters.
Ida Vogel; Poul Thorsen; Heidi Holmager Hundborg; Niels Uldbjerg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-06
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  128     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-09-11     Completed Date:  2007-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  113-8     Citation Subset:  IM    
NANEA, Institute for Public Health, Department of Epidemiology, University of Aarhus, Vennelyst Boulevard 6, 8000 Aarhus C, Denmark.
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MeSH Terms
Case-Control Studies
Gestational Age
Models, Theoretical*
Predictive Value of Tests
Pregnancy Trimesters
Premature Birth / blood*
Prospective Studies
Relaxin / blood*
Risk Factors
Reg. No./Substance:

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