| Prediction of preterm delivery among women with threatened preterm labor. | |
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MedLine Citation:
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PMID: 17339775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: To determine predictive values of fetal fibronectin and phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) in cervicovaginal secretions and ultrasonographic measurement of cervical length for delivery <35 weeks in patients with uterine contractions. METHODS: Our study included 51 women between 24 and 35 weeks' gestation with uterine contractions and 90 controls. Cervicovaginal samples were analyzed for presence of fetal fibronectin and phIGFBP-1. Cervical length was measured by transvaginal sonography. RESULTS: Preterm birth rate was 19.6% (10/51) in the study group. Negative predictive values of fetal fibronectin, phIGFBP-1 and ultrasonographic cervical length <20 mm, and <25 mm for delivery <35 weeks were 91.9, 92.3, 91.1, and 90.5%, respectively. Positive predictive values were 50, 58.3, 100 and 66.7%, respectively. When results of fetal fibronectin/phIGFBP-1 test and ultrasonographic cervical length <25 mm were combined, specificity and positive predictive values of each test for delivery within 7 days increased. CONCLUSION: Fetal fibronectin and phIGFBP-1 tests have approximately equivalent ability to predict delivery <35 weeks' gestation. An ultrasonographic cervical length measurement >20 mm or a negative fetal fibronectin/phIGFBP-1 test obtained from patients with uterine contractions at 24-35 weeks' gestation may avoid overdiagnosis. |
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Authors:
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Derya Eroglu; Filiz Yanik; Mesut Oktem; Hulusi Bulent Zeyneloglu; Esra Kuscu |
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Publication Detail:
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Type: Journal Article Date: 2007-02-23 |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 64 ISSN: 1423-002X ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-23 Completed Date: 2007-10-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: Switzerland |
Other Details:
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Languages: eng Pagination: 109-16 Citation Subset: IM |
Copyright Information:
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2007 S. Karger AG, Basel |
Affiliation:
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Department of Obstetrics and Gynecology, Baskent University Faculty of Medicine, Ankara, Turkey. d_eroglu@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / analysis Case-Control Studies Cervix Uteri / anatomy & histology, ultrasonography* Female Fibronectins / metabolism* Gestational Age Humans Infant, Newborn Infant, Premature Insulin-Like Growth Factor Binding Protein 1 / metabolism* Obstetric Labor, Premature / diagnosis* Predictive Value of Tests Pregnancy Pregnancy Trimester, Third Sensitivity and Specificity Uterine Contraction / physiology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fibronectins; 0/Insulin-Like Growth Factor Binding Protein 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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