Document Detail

Prediction of preterm birth in symptomatic women using decision tree modeling for biomarkers.
MedLine Citation:
PMID:  18395044     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of the study was to use recursive partitioning (RP) to identify gestational age-specific and threshold values for infectious and endocrine biomarkers of imminent delivery. STUDY DESIGN: RP was developed using a previously collected data set and then applied to a prospectively collected cohort of women in threatened preterm labor. Predictors of preterm birth were considered, including white blood cell count (WBC), corticotrophin-releasing hormone (CRH), cortisol, and maternal age. RESULTS: At 22-27 weeks' gestation, WBC of greater than 12,000/mL was the most accurate predictor of delivery within 48 hours; at 28-31 weeks' gestation, CRH of greater than 684 pg/mL was the most accurate predictor; and at 32-26 weeks' gestation, CRH and maternal age were the most important variables. CONCLUSIONS: These results indicate that maternal WBC greater than 12,000/mL prior to 28 weeks' gestation and CRH beyond 28 weeks are the most accurate biomarkers in predicting preterm birth within 48 hours. RP assists in establishing clinically relevant and gestational age-specific threshold levels for these variables.
Jacquelyn L Hill; M Karen Campbell; Guang Yong Zou; John R G Challis; Gregor Reid; Hiroshi Chisaka; Alan D Bocking
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  198     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-05-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  468.e1-7; discussion 468.e7-9     Citation Subset:  AIM; IM    
Department of Epidemiology and Biostatistics, the University of Western Ontario, London, ON, Canada.
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MeSH Terms
Age Factors
Biological Markers / blood
Corticotropin-Releasing Hormone / blood*
Decision Trees*
Gestational Age
Hydrocortisone / blood*
Leukocyte Count
Predictive Value of Tests
Premature Birth / blood*
Reg. No./Substance:
0/Biological Markers; 50-23-7/Hydrocortisone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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