Document Detail

Prediction of pre-eclampsia with maternal mid-trimester total renin, inhibin A, AFP and free beta-hCG levels.
MedLine Citation:
PMID:  10215068     Owner:  NLM     Status:  MEDLINE    
We wanted to study if maternal serum mid-trimester total renin, inhibin A, AFP or free beta-hCG levels predict the development of pre-eclampsia. Maternal serum alpha-fetoprotein (AFP) and human chorion gonadotrophin (beta-hCG) were evaluated in the screening programme for Down syndrome in 4356 patients prospectively. Data on pregnancy outcome were available in 1242 women. Pregnancy-induced hypertension (PIH) developed in 69 women, 282 women with uneventful pregnancy outcome were selected for controls. Serum total renin and inhibin A levels were measured retrospectively in the trisomy screening samples of 69 and 30 patients who later developed PIH, and in 282 and 7 patients, respectively, who had an uneventful pregnancy outcome. No significant differences were found in the levels of maternal mid-trimester serum total renin, inhibin A or free beta-hCG levels between PIH and healthy women. The multiples of the median (MoM) of AFP values were significantly higher in the subgroup of patients who later developed severe pre-eclampsia than in patients with mild pre-eclampsia or gestational hypertension and healthy pregnant women. Maternal mid-trimester serum levels of total renin, inhibin A and free beta-hCG are not predictive for development of PIH. High mid-trimester serum AFP values may help in the prediction of severe pre-eclampsia.
R Räty; P Koskinen; A Alanen; K Irjala; I Matinlauri; U Ekblad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  19     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-06-22     Completed Date:  1999-06-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  122-7     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Turku University Central Hospital, Finland.
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MeSH Terms
Case-Control Studies
Chorionic Gonadotropin, beta Subunit, Human / blood*
Inhibins / blood*
Pre-Eclampsia / blood,  diagnosis*
Predictive Value of Tests
Pregnancy Trimester, Second
Prenatal Diagnosis* / methods
Prospective Studies
Renin / blood*
Retrospective Studies
Sensitivity and Specificity
alpha-Fetoproteins / metabolism*
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; 0/alpha-Fetoproteins; 57285-09-3/Inhibins; EC

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