Document Detail

Prediction of persistent vaginal intraepithelial neoplasia in previously hysterectomized women by high-risk HPV DNA detection.
MedLine Citation:
PMID:  17070990     Owner:  NLM     Status:  MEDLINE    
AIM: To estimate the incidence and latency of Vaginal Intraepithelial Neoplasia (VAIN) in women previously hysterectomized for benign/malign pathology and to evaluate the role of high risk HPVs in the prediction of persistent or recurrent disease. SUBJECTS AND METHODS: 830 women with prior hysterectomy for benign/malign pathologies followed by cytological scraping and vaginal colposcopy. Forty-four patients presented VAIN lesions confirmed by histopathological diagnosis. HPV DNA test was performed at the time of diagnosis. Patients were treated by Laser CO(2) vaporization and underwent follow-up by cytology, colposcopy for a mean period of 3 years. HPV DNA test was performed at 6 months after treatment and every years. Persistent or relapsed disease was confirmed by histopathology. RESULTS: Incidence of VAIN in women hysterectomized for benign pathologies did not differ significantly from the malign group. VAIN degree was more severe in the hysterectomized patients with cervical malignancy and subsequently radiated respect to non-radiated patients. The HPV DNA test at 6 months after VAIN treatment showed fifteen positive cases: twelve HPV 16 (80%) and three HPV 18 (20%). In five cases HPV DNA test was positive with a persistent negative cytological smear during the years. Positivity to high-risk HPV (either 16 or 18) was significantly higher in the patients with relapse to VAIN (10/44, p<0.002). CONCLUSIONS: We suggest to include HPV DNA test in addition to cytology in the follow-up of patients previously treated for VAIN, in order to predict VAIN persistence or progression in vaginal carcinoma before cytology becomes abnormal.
A Frega; D French; J Piazze; A Cerekja; G Vetrano; M Moscarini
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-30
Journal Detail:
Title:  Cancer letters     Volume:  249     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-03-27     Completed Date:  2007-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  235-41     Citation Subset:  IM    
Department of Gynecology, Perinatology and Child Health, Faculty of Medicine, University "La Sapienza", Rome, Italy.
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MeSH Terms
Carcinoma in Situ / epidemiology,  virology*
DNA, Viral / analysis
Human papillomavirus 16 / genetics
Human papillomavirus 18 / genetics
Middle Aged
Papillomavirus Infections / epidemiology*,  virology
Predictive Value of Tests
Vaginal Neoplasms / epidemiology,  virology*
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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