Document Detail


Prediction of overall persistence and long-range transport potential with multimedia fate models: robustness and sensitivity of results.
MedLine Citation:
PMID:  14667728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hazard indicators persistence (P) and long-range transport potential (LRTP) are used in chemicals assessment to characterize chemicals with regard to the temporal and spatial extent of their environmental exposure. They are often calculated based on the results of multimedia fate models. The environmental and substance-specific input parameters of such models are subject to a range of methodological uncertainties and also influenced by natural variability. We employed probabilistic uncertainty analysis to quantify variance in P and LRTP predictions for chemicals with different partitioning and transport behavior. Variance found in the results is so large that it prevents a clear distinction between chemicals. Additionally, only small improvements are observed when evaluating the results relative to a benchmark chemical. This can be explained by the dominance of substance-specific parameters and the only small direct influence of environmental parameters on P and LRTP as model outcomes. The findings underline the importance of learning how environmental conditions cause variability in substance behavior for improved substance ranking and classification.
Authors:
Kathrin Fenner; Martin Scheringer; Konrad Hungerbühler
Related Documents :
10686318 - A physiological model to predict xenobiotic concentration in fish.
10948278 - Modeling the toxicity of chemicals to tetrahymena pyriformis using molecular fragment d...
14535308 - Assessing the application of an additive model to estimate toxicity of a complex effluent.
22864268 - The gamma distribution model for pulsed-field gradient nmr studies of molecular-weight ...
18706918 - Augmented sparse reconstruction of protein signaling networks.
22723118 - On the estimate of the two dominant axes of the knee using an instrumented spatial link...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental pollution (Barking, Essex : 1987)     Volume:  128     ISSN:  0269-7491     ISO Abbreviation:  Environ. Pollut.     Publication Date:  2004  
Date Detail:
Created Date:  2003-12-11     Completed Date:  2004-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804476     Medline TA:  Environ Pollut     Country:  England    
Other Details:
Languages:  eng     Pagination:  189-204     Citation Subset:  IM    
Affiliation:
Swiss Federal Institute of Technology (ETH) and Swiss Federal Institute for Environmental Science and Technology (EAWAG), CH-8600, Dübendorf, Switzerland. kathrin.fenner@eawag.ch
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Air Movements
Biodegradation, Environmental
Environmental Pollution*
Models, Theoretical
Monte Carlo Method
Sensitivity and Specificity
Time Factors
Water Movements

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Long-range transport and global fractionation of POPs: insights from multimedia modeling studies.
Next Document:  Indicators for persistence and long-range transport potential as derived from multicompartment chemi...